Funny you should ask about PIR. In January 2013, after 2.5 years LC, my BG per lab was 101 after drifiting up from the 80s, and I had been seeing 100-115 a lot at home. And when I restarted fasting this week, darn if the 100s didn't come back (though this morning was 80 again, so who knows? I now take the accuracy of home meters with a big grain of salt ).
Anyway, I wrote Dr. Westman (a patient can communicate direct) an email subject Does “Physiological Insulin Resistance” exist? And does it matter?
Part of his answer was: "I think you are making an assumption in each question below, that the 'normal values' and 'predictive ability' of measurements used routinely today in medical/preventive care, have predictive ability under nutritional ketosis circumstances.
ALL of the predictions about low carb diets were false, when data from other 'mixed diet' circumstances were used to predict what would happen under low carb conditions. In other words, you are comparing 'apples to oranges' (okay: 'bacon to brie')."
He pulled Dr. Phinney in to add to the conversation. Part of Dr. Phinney's answer was (back in Jan 2013):
"All of this was 'purely academic' until last month, when a well-regarded research group in San Francisco published a paper in 'Science' demonstrating heretofore unknown beneficial effects of beta-hydroxybutyrate (BOHB, the principal 'ketone' in human metabolism -- see attached paper if you are interested in the hard core science). What this group showed was that BOHB is a potent regulator of a group of genes that determine our body's defenses against oxidative stress, and that this effect is achieved at levels of BOHB in the blood are easily achieved on a well-formulated ketogenic diet.
Put another way, what Eric Verdin's group has shown is that besides being an excellent and continuously available fuel for the brain (as long as dietary carbs are kept low and protein moderate), BOHB is also a potent signal that stimulates genes protecting us from oxidative stress. This observation answers a number of questions that have been bugging us for a few decades, such as how a well-formulated ketogenic diet can reduce the body's level of inflammation.
So if your diet is keeping your level of oxidative stress low, then this should be reflected by a normal level of HbA1c independent of how 'high' your glucose and insulin levels might stray. And as Dr. Westman noted, the usual normal range of for fasting insulin from 3-17 has never been validated for keto-adapted humans (and given this range, none of your values are 'high'). [My fasting insulin is usually less than 5, that lab it was 9 something, so up but not bad]
All of us who were trained in allopathic medicine (ie, those of us with an 'MD' after our name) have been inculcated with a passion for reductionism. We want to attribute everything to just one causative 'agent'. In the low carb arena, insulin is an inviting reductionist target; so much so that some of our esteemed colleagues have openly declared "war on insulin". In truth, however, insulin is just a communication from some of the body's more basic responses. By analogy, declaring war on insulin is about as logical as declaring war on telephones if you don't like getting robo-calls."
Both doctors are entertaining, and I now add Dr. Fung to that select group. He has answered the "why did my BG rise when fasting?" many times on his site and DietDoctor. One of them:
Q: Should i worry if my blood sugar while fasting goes up to in the 140’s [Around 8]?
A from Dr Fung: This is quite common, and due to breakdown of glycogen or production of new glucose in response to some of the hormonal changes of fasting. It is neither good nor bad.
Think of it this way. Your body is simply moving sugar from its stores (glycogen and fat) and pushing it into the blood. Here your body has a chance to burn it off.
Seeing 99 is Ok but 101, I freak out...which is completely silly, especially with a home meter. These small rises in BG when you are eating a very ketogenic diet or fasting should not be compared to the normative values of labs for SAD folks, and there is a logical hormonal reason for them to do so. Most of my reading on PIR was from back then, but easy to find with Google. For myself, if I stray from VLCK on holidays and eat more carbs, BG goes back to the 80s very quickly.
Last edited by JEY100 : Fri, Jan-20-17 at 06:39.
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