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  #1   ^
Old Wed, Jan-18-17, 08:07
teaser's Avatar
teaser teaser is offline
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Plan: ketosis/IF
Stats: 190/158/154 Male 67inches
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Location: Ontario
Default Interesting study for people who care what happens to mice

https://www.sciencedaily.com/releas...70117140122.htm

Quote:
Scientists at the Gladstone Institutes identified an FDA-approved drug that can create the elusive and beneficial brown fat. Mice treated with the drug had more brown fat, faster metabolisms, and lower body weight gain, even after being fed a high-calorie diet. The researchers say the technique, which uses cellular reprogramming, could be a new way to combat obesity and type II diabetes.

Brown Fat Boosts Metabolism

Brown fat is different than the more commonly known white fat, which stores energy. In contrast, brown fat helps the body burn energy through heat. Infants are born with small amounts of brown fat, but as they age, most of it disappears. In adults, people with higher amounts of brown fat have lower body mass, and increasing brown fat by as little as 50 grams could lead up to a 10 to 20 pound weight loss in 1 year.

"Introducing brown fat is an exciting new approach to treating obesity and associated metabolic diseases, such as diabetes," said study first author Baoming Nie, PhD, a former postdoctoral scholar at Gladstone. "All current weight loss drugs control appetite, and there is nothing on the market that targets energy expenditure. If we can create additional stores of brown fat and boost its function in the body, we could burn off the energy stored in white fat more easily."

How to Create Brown Fat

In the new study, published in Cell Reports, scientists in the laboratory of Gladstone Senior Investigator Sheng Ding, PhD, used cellular reprogramming to convert muscle precursor cells and white fat cells into brown fat cells.

The researchers tested 20,000 chemicals until they found one that changed the identity of the cells most effectively. The winning chemical -- an anti-cancer drug called bexarotene (Bex) -- surprised the scientists, as it targets a protein that was not previously shown to be involved in generating brown fat.

Bex acts on a "master regulator" protein called retinoid X receptor (RXR), which controls a network of other cellular proteins. Activating RXR triggered a cascade of changes in muscle precursor cells and white fat that ultimately converted them into brown fat-like cells. Specifically, when RXR was stimulated by Bex, it turned on genes needed to produce brown fat and turned off genes linked to white fat or muscle.

Burn Energy, Prevent Weight Gain

To test how well Bex controls body weight, the scientists fed mice a high-calorie diet for 4 weeks, but they only treated half of the mice with the drug. The mice that were given Bex had more brown fat, burned more calories, had less body fat, and gained less weight than mice that were fed the same diet but were not given the drug.

"We're very excited about the prospect of using a drug to generate brown fat in the body," said Ding. "However, while Bex is very effective at creating brown fat cells, it is not a very specific drug, and there are several potential side effects that may arise from taking it. Our next task is to develop a safer, more targeted drug that only affects genes involved in creating brown fat."


Replacing white fat with brown fat is one thing. I wonder how many people want to send muscle precursor cells down the brown fat route, though? Also tiny little animals depend much more on brown fat for staying warm than adult humans do. I don't know how much these folk really think this will do much for human health, and how much they're just spinning the area of study that they're interested in to make funding more likely.
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  #2   ^
Old Wed, Jan-18-17, 09:48
WereBear's Avatar
WereBear WereBear is offline
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Plan: Epi-Paleo/IF
Stats: 220/169/150 Female 67
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Now if I only ate seeds and ran in a wheel...
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  #3   ^
Old Wed, Jan-18-17, 10:01
teaser's Avatar
teaser teaser is offline
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Posts: 10,270
 
Plan: ketosis/IF
Stats: 190/158/154 Male 67inches
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So hard to find a human seed-eating, wheel-running study.
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  #4   ^
Old Thu, Jan-19-17, 17:58
Ilikemice's Avatar
Ilikemice Ilikemice is offline
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Plan: Paleo-ish general LC
Stats: 151/128/123 Female 64 in
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Location: Middle Tennessee
Default

You rang?

I haven't heard about brown fat in ages. Thought it was a dead end. I wouldn't have any doubt though, as teaser alludes to, that the physiology of brown fat in meeses is completely different than humans.
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