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  #1   ^
Old Wed, Jul-09-14, 15:23
Turtle2003's Avatar
Turtle2003 Turtle2003 is offline
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Plan: Atkins, Newcastle
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Default Ketones have anticancer effects regardless of glucose levels

This is interesting - this study says that added ketones inhibit cancer tumor growth regardless of glucose levels or amount of calorie restriction.

Abstract:

Quote:
Cancer cells express an abnormal metabolism characterized by increased glucose consumption owing to genetic mutations and mitochondrial dysfunction. Previous studies indicate that unlike healthy tissues, cancer cells are unable to effectively use ketone bodies for energy. Furthermore, ketones inhibit the proliferation and viability of cultured tumor cells. As the Warburg effect is especially prominent in metastatic cells, we hypothesized that dietary ketone supplementation would inhibit metastatic cancer progression in vivo. Proliferation and viability were measured in the highly metastatic VM-M3 cells cultured in the presence and absence of β-hydroxybutyrate (βHB). Adult male inbred VM mice were implanted subcutaneously with firefly luciferase-tagged syngeneic VM-M3 cells. Mice were fed a standard diet supplemented with either 1,3-butanediol (BD) or a ketone ester (KE), which are metabolized to the ketone bodies βHB and acetoacetate. Tumor growth was monitored by in vivo bioluminescent imaging. Survival time, tumor growth rate, blood glucose, blood βHB and body weight were measured throughout the survival study. Ketone supplementation decreased proliferation and viability of the VM-M3 cells grown in vitro, even in the presence of high glucose. Dietary ketone supplementation with BD and KE prolonged survival in VM-M3 mice with systemic metastatic cancer by 51 and 69%, respectively (p < 0.05). Ketone administration elicited anticancer effects in vitro and in vivo independent of glucose levels or calorie restriction. The use of supplemental ketone precursors as a cancer treatment should be further investigated in animal models to determine potential for future clinical use.


Free full article - http://onlinelibrary.wiley.com/doi/.../ijc.28809/full
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  #2   ^
Old Wed, Jul-09-14, 16:20
squashtoo squashtoo is offline
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Plan: Atkins
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So I wonder if supplementing with ketones on a high carb diet would give you the appetite reducing effects of a lC diet.
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  #3   ^
Old Wed, Jul-09-14, 17:11
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teaser teaser is offline
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923987/

Quote:
A Ketone Ester Diet Increases Brain Malonyl-CoA and Uncoupling Proteins 4 and 5 while Decreasing Food Intake in the Normal Wistar Rat*


That's added to the food itself, though--sometimes the effect of a supplement is different when it's given in the chow than when it's put in the drinking water.
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  #4   ^
Old Wed, Jul-09-14, 17:11
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Nancy LC Nancy LC is offline
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Hmmm... very interesting! If I should ever get cancer, I'm going to try Dr. Seyfried's diet and probably augment it with coconut oil.
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  #5   ^
Old Wed, Jul-09-14, 17:28
squashtoo squashtoo is offline
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Default

So Ive seen the ketones for sale on offbeat nutrition sites. If I add it to my food I should be good to go on a pastry diet. Hmmmmm...
Every time I have a high carb day it takes about 3 days for my hunger level, energy, attitude and desire for carbs to get back in line with ketosis. It would be worth trying just to see if those symptoms would abate.
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  #6   ^
Old Wed, Jul-09-14, 17:32
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teaser teaser is offline
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The idea of a high carb/high ketone diet makes me a little nervous. Pain-free induction would be pretty cool, though.
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  #7   ^
Old Wed, Jul-09-14, 17:33
squashtoo squashtoo is offline
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Ditttttto!
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  #8   ^
Old Wed, Jul-09-14, 18:14
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Turtle2003 Turtle2003 is offline
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Plan: Atkins, Newcastle
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Default

Quote:
Originally Posted by teaser
The idea of a high carb/high ketone diet makes me a little nervous. Pain-free induction would be pretty cool, though.


Wouldn't this be similar to Wahl's protocol? I think she advocates lots and lots of veggies and then supplements with coconut or MCT oil on top of that. Been meaning to read her book.
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  #9   ^
Old Wed, Jul-09-14, 19:55
squashtoo squashtoo is offline
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Plan: Atkins
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So I found the ketones I am going to order them and wait until the next time I have an off plan day to see if it makes a difference in how I feel taking them. I will try to remember to post my experience.
I dont know about the wahls protocol. I am not really suggesting a high carb diet with ketones.
If ketones reduce the symptoms of induction they could make the difference on getting back on plan after a without agitation or aggravation.
MCT's are probably helpful too but my tolerance for them is low, Might be worth it to combine them ?
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  #10   ^
Old Wed, Jul-09-14, 20:42
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teaser teaser is offline
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Plan: mostly milkfat
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Quote:
Originally Posted by Turtle2003
Wouldn't this be similar to Wahl's protocol? I think she advocates lots and lots of veggies and then supplements with coconut or MCT oil on top of that. Been meaning to read her book.


She's still not talking high carb, is she? I had the impression it was more moderate carb. Seventy grams of carbs from veggies, plus mct oil is one thing. The standard American diet plus ketone esters is another. I know nobody here is advocating that.
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  #11   ^
Old Wed, Jul-09-14, 20:58
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Nancy LC Nancy LC is offline
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There are different levels to her diet. The most strict is pretty low carb paleo. You have to eat 6 cups of veggies a day, but they're very low carb ones like kale, collards, etc. I'd bet it is around 30-40g of net carbs.

But the purpose of the diet is for autoimmune/brain issues rather than cancer.
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  #12   ^
Old Wed, Jul-09-14, 21:28
Turtle2003's Avatar
Turtle2003 Turtle2003 is offline
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Plan: Atkins, Newcastle
Stats: 260/221.8/165 Female 5'3"
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Location: Northern California
Default

The lead on that study was Dr. Dominic D'Agostino. I've heard of him before in reference to ketogenic diets used for cancer control. Here's a TedX talk he gave. (Whoa, he looks like the Arnold Schwarzenegger of cancer researchers.)

Link
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  #13   ^
Old Thu, Jul-10-14, 06:19
M Levac M Levac is offline
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Quote:
Ketone supplementation lowered blood glucose, elevated blood ketones and decreased body weight

Talk about a CICO paradox. Increasing calories IN decreased body size.

This thread for more on cancer/ketones (reference #10 in the paper above): http://forum.lowcarber.org/showthread.php?t=447278
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  #14   ^
Old Thu, Jul-10-14, 09:35
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aj_cohn aj_cohn is offline
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Plan: Protein Power
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Default

Quote:
Originally Posted by Turtle2003
Wouldn't this be similar to Wahl's protocol? I think she advocates lots and lots of veggies and then supplements with coconut or MCT oil on top of that. Been meaning to read her book.


You should look up Dr. Eades' critique of Wahl's diet. In summary, he proposes that a nutrient-dense diet of meat (especially organ protein), fat, plus some veggies would have hastened Wahl's recovery and even improved it.
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  #15   ^
Old Thu, Jul-10-14, 11:45
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Plan: DDF
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Default

I'm not quite sure I understand that criticism. She has very specific recommendations on eating organ meats and lots of them. But she also believes there are nutrients in vegetables that we haven't even discovered yet.

This was the diet that lead to her recovery. You can speculate all you want about what diet would've improved her faster, but it isn't an experiment you can repeat (or should repeat). She makes it very clear that the recommendations she makes are because they worked for her.
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