Active Low-Carber Forums
Atkins diet and low carb discussion provided free for information only, not as medical advice.
Home Plans Tips Recipes Tools Stories Studies Products
Active Low-Carber Forums
A sugar-free zone


Welcome to the Active Low-Carber Forums.
Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

Go Back   Active Low-Carber Forums > Main Low-Carb Diets Forums & Support > Low-Carb Studies & Research / Media Watch > LC Research/Media
User Name
Password
FAQ Members Calendar Mark Forums Read Search Gallery My P.L.A.N. Survey


Reply
 
Thread Tools Display Modes
  #1   ^
Old Wed, Dec-16-09, 03:47
Demi's Avatar
Demi Demi is offline
Posts: 26,664
 
Plan: Muscle Centric
Stats: 238/153/160 Female 5'10"
BF:
Progress: 109%
Location: UK
Default Hormone that curbs hunger may guard against Alzheimer's

Quote:
BBC News
16 December, 2009

Hormone that curbs hunger may guard against Alzheimer's

High levels of a hormone that controls appetite appear to be linked to a reduced risk of developing Alzheimer's disease, US research suggests.

The 12-year-study of 200 volunteers found those with the lowest levels of leptin were more likely to develop the disease than those with the highest.

The JAMA study builds on work that links low leptin levels to the brain plaques found in Alzheimer's patients.

The hope is leptin could eventually be used as both a marker and a treatment.

The hormone leptin is produced by fat cells and tells the brain that the body is full and so reduces appetite. It has long been touted as a potential weapon in treating obesity.

But there is growing evidence that the hormone also benefits brain function.

Research on mice - conducted to establish why obese patients with diabetes often have long-term memory problems - found those who received doses of leptin were far more adept at negotiating their way through a maze.

The latest research, carried out at Boston University Medical Center, involved regular brain scans on 198 older volunteers over a 12-year period.

A quarter of those with the lowest levels of leptin went on to develop Alzheimer's disease, compared with 6% of those with the highest levels.

"If our findings our confirmed by others, leptin levels in older adults may serve as one of several possible biomarkers for healthy brain ageing and, more importantly, may open new pathways for possible preventive and therapeutic intervention."

Rebecca Wood, chief executive of the Alzheimer's Research Trust, said: "Previous studies have shown that obesity in mid-life is associated with an increased risk of dementia, but this new research suggests that leptin might have a role to play.

"There is evidence that leptin has functions in the brain - further studies in this area could lead to the possibility that this hormone plays a role in new treatments for Alzheimer's."
http://news.bbc.co.uk/1/hi/health/8414989.stm


Quote:
Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

Wolfgang Lieb, MD; Alexa S. Beiser, PhD; Ramachandran S. Vasan, MD; Zaldy S. Tan, MD; Rhoda Au, PhD; Tamara B. Harris, MD; Ronenn Roubenoff, MD, MHS; Sanford Auerbach, MD; Charles DeCarli, MD; Philip A. Wolf, MD; Sudha Seshadri, MD

JAMA. 2009;302(23):2565-2572.

Context The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes β-amyloid clearance, and improves memory function in animal models of aging and Alzheimer disease (AD).

Objective To relate baseline circulating leptin concentrations in a community-based sample of individuals without dementia to incident dementia and AD during follow-up and magnetic resonance imaging (MRI) measures of brain aging in survivors.

Design, Setting, and Participants Prospective study of plasma leptin concentrations measured in 785 persons without dementia (mean [SD] age, 79 [5] years; 62% female), who were in the Framingham original cohort at the 22nd examination cycle (1990-1994). A subsample of 198 dementia-free survivors underwent volumetric brain MRI between 1999 and 2005, approximately 7.7 years after leptin was assayed. Two measures of brain aging, total cerebral brain volume and temporal horn volume (which is inversely related to hippocampal volume) were assessed.

Main Outcome Measure Incidence of dementia and AD during follow-up until December 31, 2007.

Results During a median follow-up of 8.3 years (range, 0-15.5 years), 111 participants developed incident dementia; 89 had AD. Higher leptin levels were associated with a lower risk of incident dementia and AD in multivariable models (hazard ratio per 1-SD increment in log leptin was 0.68 [95% confidence interval, 0.54-0.87] for all-cause dementia and 0.60 [95% confidence interval, 0.46-0.79] for AD). This corresponds to an absolute AD risk over a 12-year follow-up of 25% for persons in the lowest quartile (first quartile) vs 6% for persons in the fourth quartile of sex-specific leptin levels. In addition, a 1-SD elevation in plasma leptin level was associated with higher total cerebral brain volume and lower temporal horn volume, although the association of leptin level with temporal horn volume did not reach statistical significance.

Conclusion Circulating leptin was associated with a reduced incidence of dementia and AD and with cerebral brain volume in asymptomatic older adults.


Author Affiliations: Framingham Heart Study, Framingham, Massachusetts (Drs Lieb, Beiser, Vasan, Wolf, and Seshadri); Department of Biostatistics, School of Public Health (Dr Besier), Departments of Neurology (Drs Beiser, Au, Auerbach, Wolf, and Seshadri) and Preventive Medicine and Epidemiology (Dr Vasan), School of Medicine, Boston University, Boston, Massachusetts; Boston VA Healthcare System and Division of Aging, Brigham and Women's Hospital, Boston, Masschusetts (Dr Tan); Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland (Dr Harris); Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts (Dr Roubenoff); and Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (Dr DeCarli).

http://jama.ama-assn.org/cgi/conten...02/23/2565?home
Reply With Quote
Sponsored Links
  #2   ^
Old Mon, Dec-21-09, 22:36
Sugar_Free's Avatar
Sugar_Free Sugar_Free is offline
Senior Member
Posts: 151
 
Plan: Carbs <30g/day
Stats: 131/127/125 Female 5'2"
BF:
Progress: 67%
Location: Western U.S.
Default

Could it simply be that those with less leptin eat more carbohydrate and sugar? I have heard recently of dementia sometimes being called "Diabetes III."
Reply With Quote
  #3   ^
Old Tue, Dec-22-09, 09:34
costello22's Avatar
costello22 costello22 is offline
Senior Member
Posts: 2,544
 
Plan: VLC
Stats: 265.4/238.8/199 Female 5'5.5"
BF:
Progress: 40%
Default

My understanding is that many (most?) obese people have too much leptin. Just as we tend to be insulin resistant, we're leptin resistant.
Reply With Quote
  #4   ^
Old Wed, Dec-23-09, 09:58
Beth1708 Beth1708 is offline
Senior Member
Posts: 197
 
Plan: Just no carbs
Stats: 149.6/149.4/128 Female 68
BF:
Progress: 1%
Default

I found this article on a blog: APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimer's

The author thinks that low fat & low cholesterol contribute to Alzheimer's. Go figure ...

Beth
Reply With Quote
  #5   ^
Old Wed, Dec-23-09, 12:25
Wyvrn's Avatar
Wyvrn Wyvrn is offline
Dog is my copilot
Posts: 1,448
 
Plan: paleo/lowcarb
Stats: 210/162/145 Female 62in
BF:
Progress: 74%
Location: Olympia, WA
Default

Quote:
Originally Posted by Beth1708
I found this article on a blog: APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimer's

The author thinks that low fat & low cholesterol contribute to Alzheimer's. Go figure ...

Beth
Thanks for that link. It's like a semester of lipid sci... still wading through it.
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -6. The time now is 17:40.


Copyright © 2000-2024 Active Low-Carber Forums @ forum.lowcarber.org
Powered by: vBulletin, Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.