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  #1   ^
Old Fri, Apr-24-09, 15:45
alisbabe's Avatar
alisbabe alisbabe is offline
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Plan: high fat paleo
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Default Even Modest Exercise Can Reduce Negative Effects Of Belly Fat

Quote:
ScienceDaily (Apr. 23, 2009) — A new University of Illinois study suggests that moderate amounts of exercise alone can reduce the inflammation in visceral fat—belly fat, if you will—that has been linked with metabolic syndrome, a group of risk factors that predict heart disease and Type 2 diabetes.


"In the study, the benefits of exercise were apparent, even without a change in diet. We saw improvements in insulin sensitivity, less fat in the liver, and less inflammation in belly fat," said Jeffrey Woods, a U of I professor of kinesiology and community health and faculty member in the U of I Division of Nutritional Sciences and the Integrative Immunology and Behavior Program.

Belly fat is particularly dangerous because it produces inflammatory molecules that enter the bloodstream and increase the risk of heart disease and diabetes, he said.

"Scientists now know that obesity is associated with a low-grade systemic inflammation. Obese people have higher levels of circulating inflammatory markers, such as C-reactive protein (CRP), which are produced and secreted by fat tissue. This inflammation then triggers the systemic diseases linked with metabolic syndrome, such as Type 2 diabetes and heart disease," he said.

In the study, Woods and his colleagues examined the effects of diet and exercise on the inflammation of visceral fat tissue in mice. A high-fat diet was first used to induce obesity in the animals. After 6 weeks, mice were assigned to either a sedentary group, an exercise group, a low-fat diet group, or a group that combined a low-fat diet with exercise for 6 or 12 weeks so the scientists could compare the effects in both the short and long term.

"The surprise was that the combination of diet and exercise didn't yield dramatically different and better results than diet or exercise alone," said Vicki Vieira, the lead author of the study.

"Unexpectedly, the only significant increase from 6 to 12 weeks in belly fat—the type of fat that triggers these inflammatory diseases--was in the mice who were sedentary, which suggests that exercise is an effective behavioral approach to reduce the accumulation of visceral fat even when fat in the diet is high," she said.

Woods says that is a promising finding. "The benefits of exercise were apparent even if the animals were still eating a high-fat diet. That tells me that exercise could decrease or prevent these life-threatening diseases by reducing inflammation even when obesity is still present."

"The good news is that this was a very modest exercise program. The mice ran on a treadmill only about one-fourth of a mile five days a week. For humans, that would probably translate into walking 30 to 45 minutes a day five days a week," he noted.

"Even if you struggle with dieting, we believe you can still reduce the likelihood of developing obesity-related inflammatory diseases, such as Type 2 diabetes and heart disease, by adding a modest amount of exercise to your life," said Woods.

These results were reinforced by the scientists' study of sedentary older adults published in a recent issue of Brain, Behavior and Immunity (BBI).

In that 10-month study, one group of sedentary older adults participated in three 45- to 60-minute cardiovascular exercise sessions per week, while another group focused on exercises to improve non-cardiovascular flexibility and balance for 75 minutes twice a week.

"At the end of the study, the 'cardio' group had lower levels of C-reactive protein (CRP), less belly fat, and improved general fitness than the 'flex' group," said Ph.D. candidate Vieira.

"The lower CRP levels were partially mediated by the reduction in trunk fat," she explained.

The mouse study was published in the American Journal of Physiology, Endocrinology and Metabolism. Co-authors are V.J. Vieira, R.J. Valentine, K. Wilund, N. Antao, T. Baynard, and J.A. Woods, all of the University of Illinois. The study was funded by the National Institutes of Health and the American College of Sports Medicine.

Co-authors of the BBI study are V.J. Vieira, L. Hu, R.J. Valentine, E. McAuley, E.M. Evans, T. Baynard, and J.A. Woods of the University of Illinois. Funding was provided by the National Institutes of Health.
http://www.sciencedaily.com/release...90423154237.htm

Or in other words, if you want to eat a high carb/low fat diet, you've got to exercise to reduce your heart attack risk. I'm not sure that the need to reduce inflammation is so great for low carbers. Still, I though that this was interesting.
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  #2   ^
Old Fri, Apr-24-09, 19:35
Valtor's Avatar
Valtor Valtor is offline
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http://atvb.ahajournals.org/cgi/con...tract/28/7/1368

Quote:
Background and Objective— Inflammation is pivotal in atherosclerosis. C-reactive protein (CRP), in addition to being a cardiovascular risk marker, may also be proatherogenic. We have previously shown that in addition to the liver, human aortic endothelial cells (HAECs) synthesize and secrete CRP. Whereas CRP levels are increased in obesity, metabolic syndrome, and diabetes, levels of adiponectin are reduced in these conditions. We tested the hypothesis that adiponectin reduces CRP synthesis and secretion in HAECs under normoglycemic (5.5 mmol/L glucose) and hyperglycemic conditions (15 mmol/L glucose).

Methods and Results— Adiponectin dose-dependently reduced CRP mRNA and protein from HAECs. Adiponectin treatment of HAECs significantly decreased I{kappa}B phosphorylation and NF{kappa}B binding activity. There was no effect of adiponectin on STAT or C/EBP transcriptional activity. Adiponectin also activated AMP kinase resulting in decreased NF{kappa}B activity and decreased CRP mRNA and protein. These effects of adiponectin were mimicked by AICAR, an activator of AMPK, and reversed by inhibition of AMPK. Thus, adiponectin reduces CRP synthesis and secretion from HAECs under hyperglycemia via upregulation of AMP kinase and downregulation of NF{kappa}B. Similar findings were observed in rat primary hepatocytes.

Conclusions— Thus, in obesity and diabetes, the hypoadiponectinemia could exacerbate the proinflammatory state by inducing CRP production.

We tested whether adiponectin reduces CRP synthesis and secretion in HAECs under normoglycemic (5.5 mmol/L glucose) and hyperglycemic conditions (15 mmol/L glucose). Adiponectin reduced CRP mRNA and protein under hyperglycemic conditions via upregulation of AMP kinase and downregulation of NFêB. Similar findings were observed in rat primary hepatocytes.

Exercising increases adiponectin levels, thus making you more sensitive to insulin. It looks like inhibiting the action of C-reactive protein could have the same result as increasing adiponectin (exercising).

Patrick
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  #3   ^
Old Fri, Apr-24-09, 19:59
DorianJ's Avatar
DorianJ DorianJ is offline
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Plan: Moderate Protein Atkins
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Quote:
Originally Posted by alisbabe
Or in other words, if you want to eat a high carb/low fat diet, you've got to exercise to reduce your heart attack risk.


No, if you're obese or overweight you need to exercise to reduce your heart attack risk. It's inflammation producing body fat the culprit not carbs per se. If you can consume an high-carb diet while still having a very low level of body fat you won't experience the problems of someone who can't tolerate an high carb diet and develop weight problems on it. That's why active lean people on high carb diets have low inflammation levels anyway and also why certain populations can eat high carbs without ill consequences. Sometimes the magic credited to a particular diet is just the effect of losing visceral and abdominal body fat and could have been obtained even eating mcdonald foods. In fact in response to Super Size Me, many documentaries have been created showing that as long as your hamburger and french-fries diet doesn't lead to weight gain but to weight loss, all hematic and lipid profiles improve instead of worsening ! Cholesterol, triglycerides, glycemia, insulin, inflammation, oxidative stress ... everything.
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  #4   ^
Old Fri, Apr-24-09, 22:45
melibsmile's Avatar
melibsmile melibsmile is offline
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Annnnnnd we're extrapolating to humans from mice studies again.

--Melissa
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  #5   ^
Old Sat, Apr-25-09, 06:34
teaser's Avatar
teaser teaser is offline
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The article includes a study where visceral fat was reduced in humans through exercise, so it isn't just extrapolation.

Quote:
It's inflammation producing body fat the culprit not carbs per se.


It's the visceral fat that matters most. And diet composition certainly matters. Especially fructose. I'm not saying that exercise won't help against a diet that encourages visceral fat formation; just that the crappier the diet, the more you'll have to run yourself into the ground. Maybe all those endurance athletes out there sucking back high fructose gels will get away with it.
Notice how people go on low carb diets, and sometimes, even when they aren't actively losing weight, they'll report that their waist circumference is going down? Visceral fat?
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  #6   ^
Old Sat, Apr-25-09, 07:17
Valtor's Avatar
Valtor Valtor is offline
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Plan: VLC 4 days a week
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Quote:
Originally Posted by melibsmile
Annnnnnd we're extrapolating to humans from mice studies again.

--Melissa

Tell me about it. We know so much about rats and mice now. It must be really easy for a veterinary to keep their client's rats and mice happy.

Patrick
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