Thu, Mar-27-08, 12:18
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Experimenter
Posts: 25,865
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Plan: DDF
Stats: 202/185.4/179
BF:
Progress: 72%
Location: San Diego, CA
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I'm guessing it is this study.
When you want to find out, go to pubmed.org and plug in the name of one of the authors.
Quote:
Benefit of Low-Fat Over Low-Carbohydrate Diet on Endothelial Health in Obesity
Shane A. Phillips; Jason W. Jurva; Amjad Q. Syed; Amina Q. Syed; Jacquelyn P. Kulinski; Joan Pleuss; Raymond G. Hoffmann; David D. Gutterman
From the Department of Medicine (S.A.P., J.W.J., AmjadQ.S., AminaQ.S., J.P.K., D.D.G.), Cardiovascular Center (S.A.P., J.W.J., AmjadQ.S., AminaQ.S., J.P.K., D.D.G.), and General Clinical Research Center (J.P., R.G.H.), Medical College of Wisconsin, Milwaukee; and the Department of Physical Therapy (S.A.P.), University of Illinois at Chicago.
Correspondence to Shane A. Phillips, University of Illinois at Chicago, 1919 W Taylor St, Chicago, IL 60612. E-mail shanep{at}uic.edu
Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis. Although dieting generally improves cardiovascular risk factors, the direct effect of different dietary strategies on vascular endothelial function is not known. The purpose of this study was to test the hypothesis that a low-fat (LF) diet improves endothelial function compared with an isocaloric low-carbohydrate (LC) diet. Obese (n=20; body mass index: 29 to 39; mean systolic blood pressure: 107 to 125 mm Hg) and otherwise healthy volunteers were randomly assigned to either the American Heart Association modeled LF (30% fat calories) diet or an isocaloric LC Atkins’ style diet (20 g of carbohydrates) for 6 weeks (4-week weight loss and 2-week maintenance phase). Brachial flow-mediated dilation and dilation to nitroglycerin were measured with ultrasound using automated edge detection technology (baseline, week 2, and week 6). Blood pressure, weight loss, and cholesterol profiles were measured throughout the study. Weight loss was similar in LF (100±4 to 96.1±4 kg; P<0.001) and LC (95.4±4 to 89.7±4 kg; P<0.001) diets. Blood pressure decreased similarly in both groups (LF: 8/5 mm Hg; LC: 12/6 mm Hg) at 6 weeks. After 6 weeks, the percentage of flow-mediated dilation improved (1.9±0.8; P<0.05) in the LF diet but was reduced in the LC diet (–1.4±0.6; P<0.05) versus baseline. Dilation to nitroglycerin and lipid panels was similar at 0, 2, and 6 weeks. Despite similar degrees of weight loss and changes blood pressure, LF diets improved brachial artery flow-mediated dilation over LC diets. LF diets may confer greater cardiovascular protection than LC diets.
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I think this is along the lines of that milk-shake study done awhile back. Where the high fat milk shake (with lots of sugar) had an adverse effect, while the milk shake with mono unsaturated fats had a good effect.
There's nothing new about mono-unsaturated fats doing thing generally regarded as good. But they attributed the adverse effects to saturated fats, not that perhaps mono-unsaturated fats have a good effect not found in other fats. |
The LC number is a decrease, while the LF number is an increase. A 0.6 error in the LC measurements means that the best-case scenario for LC is "only" a .8 decrease in FMD, while the worst-case scenario for LF is "only" a 1.1 increase. Combine the two and LF is still much better for FMD than LC (providing this study's results are replicated in longer trials).
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