Nothing you have provided shows any kind of proof that releasing digestive enzymes causes the pancreas to "wear out." It makes sense to lower the burden on the pancreas when it is malfunctioning due to disease or injury, but we're talking about lifelong eating habits affecting a normal pancreas, at least that's what I thought we were talking about?
I have a hypothyroid. However, nobody has suggested to me that I wore my thyroid out. Again, glands malfunctioning generally have a cause, of either disease or injury; sometimes it's "secondary," meaning another gland has problems that cause an allover imbalance.
I've heard of "adrenal burnout" on the Internet, but that's the only place.
Not necessarily. First of all, food has to travel through the stomach, and the high acidity there will denature most enzymes. Some enzymes can make it and some can't. Pancreatic enzymes are delivered directly into the small intestine, so they don't have this problem.
Also, not every enzyme does any kind of useful job for digestion. If you eat a bunch of pineapple or papaya, that might help digest any meat that you eat because both have some protein-busting enzymes, and some could make it to your intestines. But papaya enzymes don't help you digest papaya, pineapple enzymes don't help you digest pineapple.
Go on and tell me what enzymes are in raw meats, though. Maybe that's interesting?
Other enzyme examples would be the commercial products Beano and Lactaid, which are both acid-resistant enzymes that can make the journey through the stomach intact (or at least, enough of it can make it through) and then do a useful job in the colon (digest oligosaccharides in the case of Beano, and lactose in the case of Lactaid). I looked this up a while back, and they are derived from Aspergillis molds that grow on rotting vegetables, so maybe if you eat some moldy cassava raw you'd get some. However, some aspergillis molds are quite dangerous, so I don't actually recommend this.
Diabetes certainly has side effects, from rampaging blood sugar and blasts of too much insulin. My point was, I think that one side of the pancreas can have problems while the other side doesn't, at least until side effects of systemic problems kick in.