Cancer Lett. 2005 Feb 10;218(2):153-62. Related
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Inhibition of Caco-2 colon, MCF-7 and Hs578T breast, and DU
145 prostatic cancer cell proliferation by water-soluble black
bean condensed tannins.

Bawadi HA, Bansode RR, Trappey A 2nd, Truax RE, Losso JN.

Food Protein Biotechnology Laboratory, School of Human
Ecology, Louisiana State University Agricultural Center, 111
Food Science Building, Baton Rouge, LA 70803, USA.

The potential anti-angiogenic activities of water-soluble
condensed tannins isolated from black beans were evaluated
using HEL 299 normal human fibroblast lung cells, Caco-2
colon, MCF-7 and Hs578T breast, and DU 145 human prostatic
cancer cells. Condensed tannins at 0.24-24muM did not affect
the growth of normal cells, but dose-dependently induced
cancer cell death by apoptosis as shown by a
concentration-dependent decrease in ATP and cell gross
morphology. After 24h exposure to Caco-2, MCF-7, Hs578T, and
DU 145 cancer cells, water-soluble black bean condensed
tannins at 24muM suppressed fetal bovine serum stimulated cell
migration, the secretion of matrix metalloproteinase-2 (MMP-2
or gelatinase A), matrix metalloproteinase-9 (MMP-9 or
gelatinase B), and vascular endothelial growth factor
VEGF(165) receptor expression by the cancer cells in the
conditioned media. The potential health enhancing properties
of condensed tannins from black beans as inhibitors of
angiogenesis is discussed.

PMID: 15670892 [PubMed - in process]

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