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  #1   ^
Old Mon, Jul-13-09, 00:00
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Rosebud Rosebud is offline
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Default More about fructose

This is the transcript of a science based radio programme called Ockham's Razor, which aired here yesterday.

Robyn Williams: Do you know, I'm old enough to remember that shocking book called Pure, White and Deadly, written by Dr John Yudkin in the 1970s. I had him on The Science Show back in 1977, all about sugar and why it's very bad for you.

Now we have a successor. It's Sweet Poison, written here by David Gillespie, who's not a doctor but a lawyer, and loathes sugar as much as Yudkin did. Here's why.

David Gillespie: In 1865, much of what is today inner suburban Brisbane was home to vast sugar cane farms.

The farms were located there because Britain had a problem. They'd finally worked out how to make commercial quantities of refined sugar and then those pesky Americans had a civil war, stopping cane imports dead. But the demand for the white gold was insatiable and the edict went out to the empire: turn all arable land over to the production of sugar.

In the inner eastern suburbs of Brisbane, cane was planted as far as the eye could see and a floating refinery (somewhat aptly named The Walrus) plied the creeks turning out over 1,000 kilograms of sugar every day. But it was still expensive, and wasn't being eaten every day by anyone but Queen Victoria and her mates.

By 1910, sugar-based foods were starting to sneak into our diets. Cadbury had just started shipping its Dairy Maid Chocolate bar, the first-ever packaged chocolate product. In the US, Coca-Cola and Pepsi-Cola were still garage operations run out of sheds behind the pharmacies of their inventors, but were growing fast. But you still wouldn't be able to buy breakfast cereal in Australia for another 14 years. And the only place you'd be tasting fruit juice you hadn't squeezed yourself was in Church on Communion Sunday. In fact it would be 40 years before you could buy canned orange juice at all in Australia.

There weren't many overweight people. In fact four out of every five people you'd meet were downright skinny by today's standards. There was no such thing as heart disease and the medical specialty of cardiology wasn't even going to be necessary for another 25 years.

Obviously no-one was getting rich selling diets or gym-memberships. There wasn't even enough interest in diets to start a woman's magazine. The first copy of Women's Weekly wouldn't be rolling off the presses for another quarter of a century and it would be more than half a century before the first Weight Watchers meeting would happen.

Jump forward 50 years to the 1960s and things had changed a lot. Sugar was everywhere. Coke and Pepsi had grown into goliaths of the food industry. Fruit juice could be bought, refrigerated and drunk at every meal. Chocolate bars had become the lifeblood of the huge Cadbury Empire. Imitators like Nestle and Mars weren't far behind

The range of breakfast cereals had grown from the corn flakes offered in the 1920s, to thousands of high sugar concoctions. Breakfast cereal sales were doubling every nine years. That wasn't the only thing doubling. The number of overweight people in the population had doubled in just 50 years.

Heart disease was endemic, with two out of every three deaths being caused by it. A health disaster was clearly in progress, so cardiologists were trained at a rate never seen before for any profession. Medical schools were endowed with fortunes. Drug companies launched massive research programs with government money helping to grease the wheels.

To help understand why we had all suddenly gotten so fat, a new profession was invented: Human Nutrition. At the urging of the newly minted experts we all went on low-fat diets and took up the brand new sport of jogging. Never before in human history had it been necessary to run for a purpose other than catching food or getting away from danger. Sports clothing and fitness empires were created in the blink of an eye. Having shoes designed for running had never previously been necessary. And going somewhere to 'work-out' had only ever been necessary if you spent your days at Her Majesty's pleasure in a 3x3 cell.

Food manufacturers made low-fat everything. We were doing what the experts said to do, eating low-fat and exercising lots. We ate even more breakfast cereals and drank more juice and Coke because none of these things had the devil, fat, inside.

So how did that work out for us? Emergency over? Well, no, not really.

The doctors did their bit - they used all that extra money to figure out ways of replacing bits of clogged-up artery with bits from your legs. This meant that the death rate from heart disease has halved to only 1 in 3 deaths.

We did what the nutritionists told us. We started having Skinny Lattes. We stopped our children drinking milk at school because it was high in fat. We stopped having bacon and eggs for breakfast; we drank orange juice and we made sure our kids had plenty of juice to drink at school. We worked out at the gym. We got personal trainers and bought sport shoes. We pilloried McDonald's and made them introduce low-fat options and we created a whole new kind of fast food outlet, the low-fat sandwich bar.

Unfortunately, none of that worked. In fact quite the opposite. In the period from the 1960s to now, the percentage of overweight people has doubled again! Now the skinny guy is the odd man out in most rooms.

Type-2 diabetes is taking over as the new killer, and our health systems are collapsing under the weight of treating the complications of weight-related diseases that simply did not exist 40 years ago.

When these stark realities are presented to politicians, there is the usual hand-wringing and waggling of fingers at us, the slothful masses. Clearly we have not been listening to the expert advice. We need to eat less fat, and exercise more.

But the numbers tell a different story. Fat consumption has been steadily declining for 20 years. Health equipment, gym and weight loss have all gone from zero to multi-billion dollar industries in just 30 years. Forget about the internet boom, the boom in the 'health' industry has been sustained like nothing in our economic history. Twice as many people in Australia work as fitness instructors than did just 10 years ago. To mangle Winston Churchill, 'Never before have so many done so much for so little.'

Sugar purveyors like Cadbury, Coke, Pepsi, Mars and Nestle, that barely existed 99 years ago, now sit astride trillions of dollars in annual revenue. Breakfast cereal makers reap billions in profits and fully half of the US corn crop gets turned into sugar to put into soft drinks.

Is there an elephant in the room? Big Sugar (far stronger now than Big Tobacco ever was) assures us there isn't and diverts our attention with talk of everything in moderation. But the elephant is getting hard to hide. For decades there has been grumbling by researchers that couldn't prove that feeding rats fat made them fat, but could prove that feeding them sugar not only made them fat, but gave them heart disease, type-2 diabetes, fattty liver disease and testicular atrophy.

They were easily dismissed or distracted by Big Sugar and the nutritionists. Everyone knows that if you give a rat a big enough dose of anything you can make it sick, or dead. And no-one had been game to try it on humans ever since some researchers had almost killed a few of their trial participants in the early '80s.

But then someone just as powerful as Big Sugar started to look for a different answer. The drug companies that had gotten rich from cholesterol-lowering drugs started looking for a 'cure' to obesity and type-2 diabetes.

When you have to make a drug that works, it's not good enough to guess that fat causes fatness and it's not good enough to guess that exercise has anything to do with changing it. Biochemists started looking at what we actually did with our food rather than making 'educated' guesses as the nutritionists had been doing

As always, money can focus the attention of researchers, and a lot of progress was made during the '90s and noughties. Important new appetite-related hormones were discovered and what emerged from two decades of work was a scientific consensus as to how we digest food and how our appetite control system works.

They found:

We are designed for equilibrium. Like all other animals, we won't get fat unless something is broken about our appetite control system.

When we eat fat and protein a hormone is released by our gut that tells us to stop eating when we've had enough.

When we eat carbohydrates a different hormone is released by our pancreas that does the same thing.

That is true of most carbohydrates, but there is one that doesn't trip either appetite control switch: fructose. Fructose is one half of sugar. Everything that contains sugar, contains fructose.

Now that on its own wouldn't be such a big deal if we didn't eat much fructose. The worst case would be that we'd eat a few more calories than our brains thought we did.

Unfortunately, our livers are blindingly efficient at converting it to fat. Before you even finish the glass of apple juice, the fructose in the first mouthful will be circulating in your bloodstream as fat.

OK, so that's a little worrying, but still not a big deal if we don't eat much fructose.

In 1870 the average Australian's primary source of fructose was from the occasional bit of ripe fruit. And you could only get that fruit when it grew, there was no refrigerated aircraft flying bananas in from Brazil to give them to you in the middle of winter. All of that amounted to at most 1kilogram of fructose per person per year.

By the time two out of every three premature deaths were being caused by heart disease in the '60s, we'd ramped that up to 24kilograms of fructose per person per annum.

By the year 2000, we'd pushed that to 33 kilograms of fructose per person per annum, about a kilo every 10 days!

By then, almost 20% of the average person's daily calorie intake was coming from fructose. But it gets worse.

The researchers found that if you put that much fat in your arteries, you mess up the appetite control system for the foods that do trigger it.

Hormones like insulin, CCK and leptin which tell us when to stop eating, no longer work. If we're not told to stop, we keep eating and overproduction of hormones destroys our pancreas and gives us type-2 diabetes. So not only is fructose undetected and turned to fat, it actually increases the amount of other food we can eat. This is why our average daily calorie intake has increased by 30% in the last three decades.

Clearly we have an insatiable desire for sweetness, born of an evolutionary safety mechanism aimed at keeping us away from poisonous foods which were sour. Even better, if you are a fructose purveyor, it actually makes your customers want more food.

So how has something which now forms almost 20% of the average diet, crept into our food supply without anyone noticing?

The long and the short of it is the nutritionists guessed wrong when they said reduced fat and exercise was the solution. Governments didn't question the guesses and nobody invested serious money into finding out the real answer until there was an obvious buck to be turned.

Flying under the fat radar, fructose crept into every food we buy, often under the banner of making it healthier. We were told to eat more fruit and so we counted dried fruit and fruit juice as good things, and fed them to our kids.

We were told to drink less full fat milk, so we switched to zero fat alternatives, like Coke and apple juice.

We were told to avoid high fat spreads like peanut butter, so we switched to healthy honey and fruit conserves.

We were told to avoid high fat breakfasts like bacon and eggs, so we switched to healthy cereals which were a quarter to half sugar.

The miracle is not that we have all become overweight and sick. The miracle is that we are not all dead in the face of the incessant fructose doping.

So why don't we know this? The drug companies do, but they haven't the cure they were looking for, so there's not much point telling us how to solve the problem ourselves.

There's a saying in the IT industry from which I hail: 'Nobody ever got fired for buying IBM' - perhaps for the nutritionists and politicians, it's 'Nobody ever got fired for recommending a low fat high exercise diet'.

Every day that fructose remains a part of our diet, is a death sentence for thousands of Australians. So what should be done? What can be done?

The quickest and easiest solution would be to immediately ban added fructose as a food. Fructose is not necessary; it is just addictive and cheaper than the alternatives. For politicians with less intestinal fortitude, the next best option would be a regulation that requires the clear and unambiguous labelling of the fructose content of all foods. Then those of us who want to avoid it can vote with our wallets.

Robyn Williams: And it's interesting that Dr Norman Swan ran a similar fructose warning on The Health Report way back. But do keep exercising. David Gillespie is a lawyer and his book, Sweet Poison is published here by Penguin.

Next week, Professor Ian Webster, on good health care for the poor.

I'm Robyn Williams.

http://www.abc.net.au/rn/ockhamsraz...009/2621415.htm

It might be worth noting that HFCS is not used here (that I've ever seen). All of our soft drinks, for example (including Coca-Cola), are sweetened with cane sugar. Still ½ fructose, but not quite so bad as HFCS.
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  #2   ^
Old Mon, Jul-13-09, 08:48
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Nancy LC Nancy LC is offline
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It might be worth noting that HFCS is not used here (that I've ever seen). All of our soft drinks, for example (including Coca-Cola), are sweetened with cane sugar. Still ½ fructose, but not quite so bad as HFCS.

You know, the difference is very small, like 5% more fructose in HFCS than sugar.

I think it's good fructose is in the spot light because people think fruit is so healthy and they're consuming juice and what-not at incredible rates, but ultimately people are going to need to realize that sucrose sugar is pretty much just as bad.
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  #3   ^
Old Mon, Jul-13-09, 09:05
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cbcb cbcb is offline
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This wikipedia entry has a couple footnotes as to the percentages used.
http://en.wikipedia.org/wiki/High-fructose_corn_syrup

I do wonder if the percentage tells the whole story, though. Although the glucose and fructose are said to be the only two variables, I have always reacted very differently to HFCS vs. dissolved cane sugar. (So either the percentage matters that much to my body or something else about the HFCS is at play for me.)
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  #4   ^
Old Mon, Jul-13-09, 17:28
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Rosebud Rosebud is offline
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Yes, as far as I'm concerned they're both poison. I was just delighted to see the above report. Pity it didn't get reported further.
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  #5   ^
Old Mon, Jul-13-09, 18:20
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PS Diva PS Diva is offline
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Originally Posted by Nancy LC
You know, the difference is very small, like 5% more fructose in HFCS than sugar.....
but ultimately people are going to need to realize that sucrose sugar is pretty much just as bad.
I disagree. HFCS is not like natural fructose you find in fruits. It is an artificial, highly refined product. (I am not trying to say eating sugar is good, just that I think HFCS is even worse!) It is digested differently than sugar going directly to the liver. And it interferes with our ability to feel full, so that we tend to consume even more.
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  #6   ^
Old Mon, Jul-13-09, 19:23
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Nancy LC Nancy LC is offline
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I haven't seen anything that suggests our body can differentiate between fruit derived fructose and corn based fructose. Fructose, regardless of the source, is handled the same way.
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Old Tue, Jul-14-09, 07:20
DTris DTris is offline
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Quote:
Originally Posted by Nancy LC
I haven't seen anything that suggests our body can differentiate between fruit derived fructose and corn based fructose. Fructose, regardless of the source, is handled the same way.


One difference.

Quote:
Pure fructose contains no enzymes, vitamins or minerals and robs the body of its micronutrient treasures in order to assimilate itself for physiological use.7 While naturally occurring sugars, as well as sucrose, contain fructose bound to other sugars, high fructose corn syrup contains a good deal of "free" or unbound fructose. Research indicates that this free fructose interferes with the heart’s use of key minerals like magnesium, copper and chromium. Among other consequences, HFCS has been implicated in elevated blood cholesterol levels and the creation of blood clots. It has been found to inhibit the action of white blood cells so that they are unable to defend the body against harmful foreign invaders.8

Quote from http://www.westonaprice.org/modernf...ghfructose.html

Also Fructose in fruit is L-Fructose of Levulose. Fructose in HFCS is D-fructose which has the reversed isomerization and polarity of a refined L-fructose molecule. D-fructose is not recognized by the human body for primary conversion in the human krebs cycle, in other words it cannot produce energy directly. So it is primarily converted to adipose tissue and triglycerides. Obese people who drink fructose sweetened beverages with a meal have blood triglyceride levels up to 200% higher than those who drink glucose sweetened beverages.

Above info paraphrased from http://www.westonaprice.org/modernfood/HFCSAgave.pdf
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  #8   ^
Old Tue, Jul-14-09, 07:38
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PS Diva PS Diva is offline
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Quote:
Originally Posted by Nancy LC
I haven't seen anything that suggests our body can differentiate between fruit derived fructose and corn based fructose. Fructose, regardless of the source, is handled the same way.
I would have to agree that more studies have been done comparing the differences between sugar and HFCS than fructose and HFCS. Even so, I don't want to eat something that has been chemically altered as much as HFCS has been!
Quote:
HFCS is manufactured from cornstarch after the removal of protein and fiber. The cornstarch is hydrolyzed to form dextrose, which then undergoes an isomerization process to yield different forms of HFCS that vary depending on the final fructose content. HFCS therefore contains other components in addition to fructose, the majority of which is glucose with minor contributions of other substances including maltose, maltotriose, and polydextrose. In contrast, crystalline fructose is purified and does not contain appreciable amounts of other components.
http://www.metaproteomicslabs.com/pp-fructose.asp

I personally am interested in the glycemic index. Fructose is on the low end, relatively speaking. HFCS is higher.
Quote:
The high glycemic index of HFCS in our study does not support the use of HFCS as a substitute for fructose.
http://www.ncbi.nlm.nih.gov/pubmed/2695593
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  #9   ^
Old Tue, Jul-14-09, 08:41
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Nancy LC Nancy LC is offline
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I personally am interested in the glycemic index. Fructose is on the low end, relatively speaking. HFCS is higher.
It doesn't matter, it still ends up in the liver and getting processed there.

Just because the glucose and fructose are bound together in sucrose means nothing. We have digestive enzymes that split them apart in our gut and Mr. Fructose still goes to the liver to get processed. Yes, that's why it is low glycemic, it doesn't go directly into the blood like glucose does. But it's far more insidious than glucose. That's partly why I think the GI Index is pretty much worthless.

I'm not saying that all fruit is evil and you should never eat it, I think it has a place in the diet if one wants a treat, but if you're consuming a lot of it, or if you're getting it in concentrated sources, like juice, then I think you might as well be chugging corn syrup because fructose is fructose and your liver doesn't care what the source is, it's going to end up raising your triglycerides and getting stored in the liver and contribute towards non-alcoholic fatty liver disease and Type II diabetes (not to mention obesity).

WAPF are doctors (and nutritionists). They may were lab coats but they're not scientists. Show me some clinical studies that differentiate between fruit based fructose and corn based fructose or even the fructose in sugar and I might change my viewpoint.

It's a shame because people don't realize the scam that Agave syrup makers are pulling. That stuff is basically far worse than HFCS but because it is sold in Health food stores, it gets a pass. It's highly processed and even the FDA is starting to come down on them for it, thankfully. But it has this patina of saintliness because it is "low glycemic". I bet rat poison is low glycemic too.

The obesity epidemic]The obesity epidemic
Good stuff in here about fructose. Including: Fructose actually is a hepato-toxin; now fructose is fruit sugar but we were never designed to take in so much fructose. Our consumption of fructose has gone from less than half a pound per year in 1970 to 56 pounds per year in 2003.
Good grief!
And
Quote:
Robert Lustig: No, actually it's not the calories that are different it's the fact that the only organ in your body that can take up fructose is your liver. Glucose, the standard sugar, can be taken up by every organ in the body, only 20% of glucose load ends up at your liver. So let's take 120 calories of glucose, that's two slices of white bread as an example, only 24 of those 120 calories will be metabolised by the liver, the rest of it will be metabolised by your muscles, by your brain, by your kidneys, by your heart etc. directly with no interference. Now let's take 120 calories of orange juice. Same 120 calories but now 60 of those calories are going to be fructose because fructose is half of sucrose and sucrose is what's in orange juice. So it's going to be all the fructose, that's 60 calories, plus 20% of the glucose, so that's another 12 out of 60 -- so in other words 72 out of the 120 calories will hit the liver, three times the substrate as when it was just glucose alone.

That bolus of extra substrate to your liver does some very bad things to it.

Last edited by Nancy LC : Tue, Jul-14-09 at 10:05.
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  #10   ^
Old Tue, Jul-14-09, 08:53
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Wifezilla Wifezilla is offline
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Mr. Fructose still goes to the liver to get processed. Yes, that's why it is low glycemic, it doesn't go directly into the blood like glucose does. But it's far more insidious than glucose. That's partly why I think the GI Index is pretty much worthless.

Exactly. While someone following a low GI diet might see benefits by eliminating white flour and sugar, they could EASILY negate that by raising their triglycerides by eating too much fruit.

And I also agree about agave syrup.

"Agave syrup, a refined fructose product is being cleverly marketed in the health food industry as a wholesome, natural, low glycemic sweetener. Even the word “nectar” is deceiving, as if it is dripping fresh from flowers or fruit.

Agave nectar, or more accurately refined fructose agave syrup was created in the 1990’s using technology devised by corn refiners to chemically convert corn starch to corn syrup, known as high fructose corn syrup, the sweetener that has done much to increase obesity, insulin resistance and increased heart disease and diabetes. The main carbohydrate in agave is starch, which, like corn starch, is chemically converted to highly refined fructose.

The sugar that comes from fruit is levulose. The word “fructose” is cleverly used by corn refiners to make you think it is a natural fruit sugar.

Fructose is not absorbed like other sugars. It does not go directly into the bloodstream, but instead it goes to the liver where it is converted to triglycerides and fat. “Low glycemic” makes it sound safe. It is anything but safe. High fructose corn syrup is 55% fructose. Agave “nectar” is about 70% fructose.

While refined fructose agave syrup won’t spike your blood sugar levels, it will deplete minerals, inflame the liver, harden the arteries, cause insulin resistance leading to diabetes, obesity and cardiovascular disease, and may be toxic for use during pregnancy."
http://healthandnutritionexperts.wo...d-agave-nectar/
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  #11   ^
Old Tue, Jul-14-09, 09:38
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PS Diva PS Diva is offline
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As I understand it, when sucrose enters your stomach, the molecules are split apart and the fructose heads off to the liver, and the glucose enters the bloodstream. In HFCS we have the additional problem of the molecules being unstable and thus forming reactive carbonyls that enter the bloodstream. Reactive carbonyls have been linked to tissue damage.


Quote:
That's partly why I think the GI Index is pretty much worthless.
Perhaps we can't agree on whether or not the glycemic index is useful, but can we agree that with the advent of HFCS one of the things that has happened is that they are adding this sweetener to things that they didn't use to add sweetener to at all. Like salad dressings. Or crackers! And did there used to be so much added sweetening to mayonaise? Or am I just more aware of it now?
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  #12   ^
Old Tue, Jul-14-09, 09:50
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Nancy LC Nancy LC is offline
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Actually, sugar and fruit might even be worse than simple fructose.
Quote:
Studies show the greatest absorption rate occurs when glucose and fructose are administered in equal quantities [18]. When fructose is ingested as part of the disaccharide sucrose, absorption capacity is much higher because fructose exists in a 1:1 ratio with glucose. It appears that the GLUT5 transfer rate may be saturated at low levels and absorption is increased through joint absorption with glucose [19]. One proposed mechanism for this phenomenon is a glucose-dependent cotransport of fructose. In addition, fructose transfer activity increases with dietary fructose intake. The presence of fructose in the lumen causes increased mRNA transcription of GLUT5, leading to increased transport proteins. High fructose diets have been shown to increase abundance of transport proteins within 3 days of intake. [20]
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  #13   ^
Old Tue, Jul-14-09, 10:06
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Nancy LC Nancy LC is offline
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As I understand it, when sucrose enters your stomach, the molecules are split apart and the fructose heads off to the liver, and the glucose enters the bloodstream. In HFCS we have the additional problem of the molecules being unstable and thus forming reactive carbonyls that enter the bloodstream. Reactive carbonyls have been linked to tissue damage.

Even if this is true, there's still all the issues about flooding your liver with fructose sugar.
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Old Tue, Jul-14-09, 10:32
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PS Diva PS Diva is offline
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We are really not so far apart on this!!
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Old Tue, Jul-14-09, 15:01
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cbcb cbcb is offline
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Quote:
Originally Posted by Nancy LC
Show me some clinical studies that differentiate between fruit based fructose and corn based fructose or even the fructose in sugar and I might change my viewpoint.


Can you provide links to clinical studies proving that they are handled the same way through the metabolic cycle?
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