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  #1   ^
Old Thu, Oct-18-18, 09:12
teaser's Avatar
teaser teaser is offline
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Default ketones versus hypertension

https://www.sciencedaily.com/releas...81016132006.htm

Quote:
Couch potatoes rejoice -- there might be a way to get the blood pressure lowering benefits of exercise in pill form.

Hypertension researchers at The University of Toledo have shown that by increasing the body's supply of beta hydroxybutyrate, a chemical produced predominantly by the liver, it is possible to regulate high blood pressure without reducing sodium intake or increasing exercise.

"Our team found that high salt consumption lowered levels of circulating beta hydroxybutyrate. When we put beta hydroxybutyrate back in the system, normal blood pressure is restored," said Dr. Bina Joe, Distinguished University Professor and chair of UT's Department of Physiology and Pharmacology and director of the Center for Hypertension and Precision Medicine. "We have an opportunity to control salt-sensitive hypertension without exercising."

The team's findings were published Tuesday in the Oct. 16 issue of the life sciences journal Cell Reports.

Beta hydroxybutyrate is a ketone body produced in the liver from the metabolism of fatty acids. It had not been previously explored as a method for controlling blood pressure, but the UT researchers noted a number of intriguing connections between how the body produces beta hydroxybutyrate and environmental factors known to raise or lower blood pressure.

"As we searched through the literature we saw beta hydroxybutyrate has been observed increasing with exercise or calorie restriction. Both of those activities also reduce blood pressure. The key piece of our discovery is we now know that beta hydroxybutyrate decreases with salt consumption. This is a novel mechanism by which salt is tied to an increase in blood pressure," said Saroj Chakraborty, a fourth-year PhD student in the UT Department of Physiology and Pharmacology and the paper's lead author.

To test its hypothesis, the team led by Chakraborty and Joe developed a study in which they fed lab rats a chemical called 1,3-butanediol.

When that supplement reaches the liver, enzymes convert it to beta hydroxybutyrate. From there, it goes to the kidney where it was shown to reduce inflammation commonly associated with hypertension -- and significantly decrease blood pressure in the process.

"By fixing the kidney it is indirectly contributing to the lowering of blood pressure. There could be many other organs that it is impacting," Joe said. "We are studying the heart, blood vessels, brain and other organ systems. But this paper says that this molecule, predominately made in the liver, goes to the kidney, fixes kidney damage and controls your blood pressure."

Joe noted that controlling function of the liver to regulate blood pressure is a new concept for researchers.

UT has received a provisional patent on the concept. Researchers in Joe's lab next want to compare the level of beta hydroxybutyrate in hypertensive patients against those without high blood pressure. Further studies also will determine how much 1,3-butanediol is needed to modulate blood pressure and whether it might cause any potential damage to other organs.

Once the team collects that data, the researchers hope to secure funding for a clinical trial.

While lowering blood pressure without hitting the gym might sound appealing to those averse to breaking a sweat, it also could prove beneficial to those who aren't able to exercise.

"There are certain patients who are not able to exercise for various reasons. This could prove to be a legitimate alternative for those individuals," Chakraborty said.





https://www.cell.com/cell-reports/f...Fshowall%3Dtrue

No mention of the ketogenic diet in the study itself. Lots in other studies that it cites.

The ketone supplementation--ketones are high both in the fasted and fed states--there's an overcompensation for what looks like a slightish decrease in fasted ketosis in the rodents on the increased salt diet. I'm not sure I buy ketone deficiency being the cause--ketones being therapeutic doesn't necessarily mean that their lack is the problem.

Also of course the question of whether you're a rat model of salt-induced hypertension or not.
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  #2   ^
Old Thu, Oct-18-18, 10:07
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GRB5111 GRB5111 is offline
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Yeah, intriguing, but confusing. I agree that ketones (BHB) or lack of needs further investigation in a relationship with HBP. How salt impacts ketones with relation to HBP in humans should be safe and easy to determine . . .
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  #3   ^
Old Thu, Oct-18-18, 10:10
M Levac M Levac is offline
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Never mind it's a rat thing. In my paradigm, it says ketones activate insulin receptors especially in the liver where insulin is degraded and excess glucose is stored, in turn this causes insulin and glucose to drop. There may be a mechanism where excess insulin and/or excess glucose causes blood pressure to rise. If this is the case, then we don't need to invoke ketones acting on the kidneys, the drop in insulin and glucose is already enough to explain the observation. On the other hand the ketones-kidneys effect could merely occur in parallel.

But of course we can't tell people to go low-carb, how we gonna sell drugs?

-edit- Forgot. My paradigm also says by virtue of the mechanism I explained above, absence of ketones is the proximal cause of insulin resistance.
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  #4   ^
Old Thu, Oct-18-18, 10:22
teaser's Avatar
teaser teaser is offline
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Plan: mostly milkfat
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Even if people keep ending up at blah blah blah drugs to mimick ketones blah, I still welcome their contribution. Lipid metabolism, lipoproteins etc. may have been better studied because people hoped to find drug targets than it otherwise would have been--at the least it's probably been better funded.
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  #5   ^
Old Thu, Oct-18-18, 10:24
GRB5111's Avatar
GRB5111 GRB5111 is offline
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Plan: Very LC, Higher Protein
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BHBs, the new blood pressure meds . . . ? We shall see . . .
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  #6   ^
Old Thu, Oct-18-18, 17:09
Zei Zei is offline
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If someone has a type of high blood pressure that's due to salt sensitivity how does hitting the gym for exercise fix that?
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