I read insulin resistance and it always bugs me. Nobody ever explained to me in a reasonable way why it's important, or what in fact it actually is. Well, let's see. What's the context? Glucose disposal, plain and simple. But what's the context of glucose disposal? Excess glucose disposal, also plain and simple. So, the only reason insulin resistance is important is within the context of a high-carb diet, just as plain and simple as the rest. What if we eat a low-carb diet, why should insulin resistance be important then? We got no excess glucose to dispose of. Indeed, the most likely primary cause of insulin resistance is excess glucose. So, once we eat low-carb, there is no reasonable expectation of insulin resistance to occur, or if it does occur to a level which would otherwise disrupt proper disposal of excess glucose specifically, to consider it important for the purpose of excess glucose disposal, since we got no excess glucose to dispose of.
The context of low-carb does not fit standard insulin resistance. We need a new standard for this, and a new way to measure this new standard. I propose that a priori, three parameters be used to determine basic insulin resistance: BG, blood ketones, blood insulin. The ratio of the three tells us several things all at once. With standard insulin resistance, glucose is used in several tests. Within the context of low-carb, using glucose does not serve our purpose. We have no need for any information regarding how quickly we dispose of excess glucose, when we don't normally dispose of excess glucose. However, we do have need of other information regarding, for example, how well we regulate ketogenesis in the liver, and for this we would need to use ketones rather than glucose. So again for example, if we inject ketones in the blood, we should expect to see a drop in both BG and insulin. If we don't see this effect, then it's obvious the liver isn't regulating ketogenesis properly, and here we have some tangible information that concerns us. Once we establish a standard for these measures, i.e. dose-response for example, we can more easily determine insulin resistance as it relates to us as a group and to us individually. But until then, we're just talking.
The point is anybody who talks about insulin resistance within the context of low-carb doesn't actually know what he's talking about, cuz you know, there ain't no data on that.
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