Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome.
OBJECTIVES:
Women with PCOS frequently suffer from metabolic disturbances, in particular from insulin resistance.
Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome.
Hence, the aim of our study was to investigate the association of 25(OH)D levels and the components of the MS in PCOS women.
METHODS: 25(OH)D levels were measured by means of ELISA in 206 women affected by PCOS. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed. RESULTS: The prevalence of insufficient 25(OH)D levels (<30 ng/ml) was 72.8% in women with PCOS.
PCOS women with the MS had lower 25(OH)D levels than PCOS women without these features (17.3 vs 25.8 ng/ml respectively.
In multivariate regression analysis including 25(OH)D, season, body mass index, and age, 25(OH)D and BMI were independent predictors of homeostatic model assessment-insulin resistance and quantitative insulin sensitivity check index
. In binary logistic regression analyses, 25(OH)D and BMI were independent predictors of the MS in PCOS women.
We found significantly negative correlations of 25(OH)D levels with BMI, waist circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting and stimulated glucose, area under the glucose response curve, fasting insulin, HOMA-IR, HOMA-beta, triglycerides, and quotient total cholesterol/high-density lipoprotein (HDL) and positive correlations of 25(OH)D levels with QUICKI and HDL.
CONCLUSION:
We demonstrate that low 25(OH)D levels are associated with features of the MS in PCOS women.
Large intervention trials are warranted to evaluate the effect of vitamin D supplementation on metabolic disturbances in PCOS women.
I disagree with the last statement.
Vitamin D supplementation at up to 10,000iu/daily is absolutely safe and extremely cheap.
The natural level of 25(OH)D our body would naturally acquire given full body sun exposure is around 60~80ng/ml
Therefore there is absolutely no good reason why any person should not correct vitamin D deficiency NOW and when they have attained and maintained a 25(OH)D above 55ng/ml for at least 12months report back on the impact such a status has had on the symptoms of PCOS.
There are so many other good reasons, cancer prevention, heart disease prevention, diabetes prevention, just for starters that it is absurd to go on saying we need to wait for further trials before suggesting people correct vitamin D deficiency states. We wouldn't say that for someone suffering from water for food deficiency so why delay when we are discussing PCOS?
Anyone who knows that
The prevalence of insufficient 25(OH)D levels (<30 ng/ml) was 72.8% in women with PCOS. should do something about it.
Those women have less than half the amount of vitamin d that enables their breasts to work as human DNA evolved to function that is capable of dispensing vitamin D3 replete breast milk.
Every woman with less than 55ng/ml status is at greater risk of breast cancer than is desirable. So why anyone suggests further delay is beyond me.
In order to obtain peak athletic muscular performance you must have a vitamin D status above 50ng/ml.
So around half that amount it's fine is it for women to be kept weaker than they should naturally be?
So on all the tests they ran those with the lowest vitamin D status came out worst and they still need to do more tests before they can recommend the Bl***** Obvious.