Wed, Oct-17-18, 19:14
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Doing My Best
Posts: 4,924
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Plan: LC/CancerRecovery
Stats: 170/135/130
BF:24%
Progress: 88%
Location: Nevada Desert, USA
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Quote:
Neuroprotective and disease-modifying effects of the ketogenic diet
Maciej Gasior,a Michael A. Rogawski,a and Adam L. Hartmana,b
Author information ► Copyright and License information ► Disclaimer
The publisher's final edited version of this article is available at Behav Pharmacol
Abstract
The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer long-lasting therapeutic benefits for patients with epilepsy. Moreover, there is evidence from uncontrolled clinical trials and studies in animal models that the ketogenic diet can provide symptomatic and disease-modifying activity in a broad range of neurodegenerative disorders including Alzheimer’s disease and Parkinson’s disease, and may also be protective in traumatic brain injury and stroke. These observations are supported by studies in animal models and isolated cells that show that ketone bodies, especially β-hydroxybutyrate, confer neuroprotection against diverse types of cellular injury. This review summarizes the experimental, epidemiological and clinical evidence indicating that the ketogenic diet could have beneficial effects in a broad range of brain disorders characterized by the death of neurons. Although the mechanisms are not yet well defined, it is plausible that neuroprotection results from enhanced neuronal energy reserves, which improve the ability of neurons to resist metabolic challenges, and possibly through other actions including antioxidant and anti-inflammatory effects. As the underlying mechanisms become better understood, it will be possible to develop alternative strategies that produce similar or even improved therapeutic effects without the need for exposure to an unpalatable and unhealthy, high-fat diet.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/
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So the only thing we here on this forum disagree with are the last few words: ".....without the need for exposure to an unpalatable and unhealthy, high-fat diet."
This brings me to the subject of exogenous ketones:"The idea is when you eat something that's not keto-friendly, you can reach for exogenous ketones to keep your body in ketosis. The word exogenous means created externally, and these supplements are forms of the ketone beta-hydroxybutyrate (BHB), which your body normally creates on its own."
So the question from me is this: If I eat SAD and take exogenous ketones, will I still be protected? Will my aches and pains (currently depressed by ketosis) remain depressed by "artificial" ketosis?
Next time I go off plan, I should do that n=1. Or has it already been tried.
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