Mon, Sep-11-17, 05:49
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Senior Member
Posts: 15,075
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Plan: mostly milkfat
Stats: 190/152.4/154
BF:
Progress: 104%
Location: Ontario
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https://www.youtube.com/watch?v=Gm626MgpveI
Quote:
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Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation
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I thought people interested in fasting and autophagy might like this interview. Some interesting factoids. He mentions exercise being ineffective vs. diabetes in mice if you block autophagy. Also, the calorie restriction researchers often fail to popularize some of their observations. One is the decrease in immune function that can lead to increased death from infection. Another--the mice have to be individually caged, to keep them from filling up on other mice.
Also touches on the difficulty of ascertaining autophagy in humans vs mice and in intact animals vs. cell cultures. A common claim is that any amount of protein, even micrograms in coffee, will shut down autophagy, Dr. Fung himself has said this. But this is based on cell cultures, were the extracellular amino acids available to the cells can be brought to a very low level, lower than can happen in an intact animal. If you're worried about micrograms of amino acids from coffee shutting down autophagy, you'd better be very concerned about the hundreds of grams of protein turnover that happens in a human being daily, whether they ate or not. The liver secretes quite a bit of protein into the intestine to be digested and recycled, on a daily basis. Incidentally, he also brings up a study he was involved in where coffee increased autophagy. This isn't to knock people who just stick to water during the non-eating part of their IF, for one thing, abstaining can be safer than the slippery road of "just a little bit of this couldn't hurt."
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