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  #1   ^
Old Mon, Jan-26-15, 11:01
patriciakr's Avatar
patriciakr patriciakr is offline
Senior Member
Posts: 6,734
 
Plan: CALP with Primal Leanings
Stats: 368/291.2/160 Female 5' 4
BF:toodmnmch
Progress: 37%
Location: In the woods
Default Help or link to help re understanding my Lipoprotein NMR 600 results



Lipid panel (done the same day) - had been fasting for about 15 hours.
chol: 266 range: 0-199
Trig: 41 0-149
HDL: 84 40-90
LDL chol: 174 0-130
LDL/HDL Ratio: 2.1
Chol/HDL ratio: 3.2 0.0-5.0
Non HDL Chol (LDL + VLDL) Calc: 182 0-159

Lipoprotein NMR 600

LDL-P: 1669 range: <1000 nmol/L
LDL Chol Calc: 175 <100 mg/dl
HDL: 76 >39 mg/dl
Trig, total: 56 <150 mg/dl
Chol, total: 262 <200 mg/dl
HDL-P total: 30.8 >30.4 umol/L
Small LDL-P: <90 <528 nmol/L
LDL Size: 21.8 >20.5 nm
LP-IR Score: <25 <46

Help? Am I right that I have larger size LDL - the fluffy kind since I have a low small ldl-p?
How concerned should I be re my LDL-P#?

Thanks in advance for any help or link to a decent explanation.
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  #2   ^
Old Tue, Jan-27-15, 07:57
patriciakr's Avatar
patriciakr patriciakr is offline
Senior Member
Posts: 6,734
 
Plan: CALP with Primal Leanings
Stats: 368/291.2/160 Female 5' 4
BF:toodmnmch
Progress: 37%
Location: In the woods
Default

Okay I'll beg...I've figured out some of this - been reading the other posts on this and folks results, but I sure would appreciate someone kindly taking the time to respond.

Thank you in advance
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  #3   ^
Old Tue, Jan-27-15, 08:53
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,863
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
Default

I did not reply because I don't know. Have you googled? I just did and got a huge number of responses to "nmr results" including this one from Mark's Daily Apple:

http://www.marksdailyapple.com/how-.../#axzz3Q29atooh

If you choose to share the results of your researching, I'm sure someone will be able to use it down the line. It seems there is no dearth of information available out there.

I'm getting less and less interested in cholesterol testing as time goes by. I'm female, getting older, low carbing, and I know that whatever some lab comes up with it is numbers on a piece of paper, not a reflection of my actual health.
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  #4   ^
Old Tue, Jan-27-15, 09:23
JEY100's Avatar
JEY100 JEY100 is online now
Posts: 13,431
 
Plan: P:E/DDF
Stats: 225/150/169 Female 5' 9"
BF:45%/28%/25%
Progress: 134%
Location: NC
Default

Go to LipoScience's own page. More info than if you just look at a LabCorp result. But drat, the page I had bookmarked is gone. Replaced with a new one...I don't have time to check now if all the same info. Be back later.
Trigs and HDL are great!


http://www.theparticletest.com/nmr-...ur-test-results

http://www.theparticletest.com/site...ienttearpad.pdf
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  #5   ^
Old Tue, Jan-27-15, 09:27
patriciakr's Avatar
patriciakr patriciakr is offline
Senior Member
Posts: 6,734
 
Plan: CALP with Primal Leanings
Stats: 368/291.2/160 Female 5' 4
BF:toodmnmch
Progress: 37%
Location: In the woods
Default

Quote:
Originally Posted by Nancy LC
I did not reply because I don't know. Have you googled? I just did and got a huge number of responses to "nmr results" including this one from Mark's Daily Apple:

http://www.marksdailyapple.com/how-.../#axzz3Q29atooh

If you choose to share the results of your researching, I'm sure someone will be able to use it down the line. It seems there is no dearth of information available out there.

I'm getting less and less interested in cholesterol testing as time goes by. I'm female, getting older, low carbing, and I know that whatever some lab comes up with it is numbers on a piece of paper, not a reflection of my actual health.

Hi Nancy,
Me too but I have a cardiologist I love, to convince. lol. I did google, I binged (as in bing, not binged!), I read mark's post, some of Dr. Attias, and I'm not seeing what I think is either missing or I'm being dense..the whole reason I wanted this test was to determine my ldl particle size/shape. I told my cardiologist that despite making some (to me) drastic changes this past year, I didn't expect my total cholesterol to improve (and it didn't though my hdl got nicer). I've told him I think I have large fluffy ldl and the number doesn't really matter.
But darned if I can tell for sure, that that is what my results are saying.

I *think* based on what I've read, that with my low trigs and high HDL, that means my ldl is the large and fluffy variety
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  #6   ^
Old Tue, Jan-27-15, 09:29
patriciakr's Avatar
patriciakr patriciakr is offline
Senior Member
Posts: 6,734
 
Plan: CALP with Primal Leanings
Stats: 368/291.2/160 Female 5' 4
BF:toodmnmch
Progress: 37%
Location: In the woods
Default

Quote:
Originally Posted by JEY100
Go to LipoScience's own page. More info than if you just look at a LabCorp result. But drat, the page I had bookmarked is gone. Replaced with a new one...I don't have time to check now if all the same info. Be back later.
Trigs and HDL are great!


http://www.theparticletest.com/nmr-...ur-test-results

http://www.theparticletest.com/site...ienttearpad.pdf

Thanks Jey100 will do. So far, the "how to interpret your test results" pages I've visited were more general - here is why high LDL-P is bad( and a nice graph to show you the degrees of bad - please note I'm saying this with a sarcastic tone), versus a simple if your ldl-p size is this, it means...

Sigh.
update: I had seen both of those pages. Just not going into the rest of my results that I am curious about - the significance of my small LDL-P result, my LDL size, my LP-IR score.
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  #7   ^
Old Tue, Jan-27-15, 09:35
Liz53's Avatar
Liz53 Liz53 is offline
Senior Member
Posts: 6,140
 
Plan: Mostly Fung/IDM
Stats: 165/138.4/135 Female 63
BF:???/better/???
Progress: 89%
Location: Washington state
Default

I've never had this test but Dr Thomas Dayspring is an advocate and one of the big experts. Jimmy Moore interviewed him a couple of years back on his Ask the LowCarb Experts show. http://www.askthelowcarbexperts.com...t-matters-most/ I recall he says a high particle number can be a problem even if you have large fluffy LDL.

Here's a paper he wrote recently on dissecting what's important and what's not and when statins are in order (he does believe in statins for some cases):
https://www.lipidcenter.com/pdf/Und...pid_Profile.pdf

Also, someone on my "buddy" thread had these tests a few months back and was able to lower her particle number by reducing sat fats, I believe. I've sent her a link to this thread. Maybe she will have some further info for you.
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  #8   ^
Old Tue, Jan-27-15, 10:18
patriciakr's Avatar
patriciakr patriciakr is offline
Senior Member
Posts: 6,734
 
Plan: CALP with Primal Leanings
Stats: 368/291.2/160 Female 5' 4
BF:toodmnmch
Progress: 37%
Location: In the woods
Default

Quote:
Originally Posted by Liz53
I've never had this test but Dr Thomas Dayspring is an advocate and one of the big experts. Jimmy Moore interviewed him a couple of years back on his Ask the LowCarb Experts show. http://www.askthelowcarbexperts.com...t-matters-most/ I recall he says a high particle number can be a problem even if you have large fluffy LDL.

Here's a paper he wrote recently on dissecting what's important and what's not and when statins are in order (he does believe in statins for some cases):
https://www.lipidcenter.com/pdf/Und...pid_Profile.pdf

Also, someone on my "buddy" thread had these tests a few months back and was able to lower her particle number by reducing sat fats, I believe. I've sent her a link to this thread. Maybe she will have some further info for you.

Thank you!
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  #9   ^
Old Tue, Jan-27-15, 11:03
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,863
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
Default

That particle number thing is not undisputed. There was a thread here recently on that.

I remember my test, I think it was a VAP test, had particle size. Trending toward "A" was good, but "B" was bad (small particles).
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  #10   ^
Old Tue, Jan-27-15, 11:21
Liz53's Avatar
Liz53 Liz53 is offline
Senior Member
Posts: 6,140
 
Plan: Mostly Fung/IDM
Stats: 165/138.4/135 Female 63
BF:???/better/???
Progress: 89%
Location: Washington state
Default

Quote:
Originally Posted by Nancy LC
That particle number thing is not undisputed. There was a thread here recently on that.



Very true. I personally think it is unsettled science at this point. Maybe that's why the results page that JEY posted is so bland and it's difficult to find anything very definitive. However, I think Dayspring's opinions should be weighed along with the rest of them.
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  #11   ^
Old Tue, Jan-27-15, 14:55
janjfree's Avatar
janjfree janjfree is offline
Senior Member
Posts: 1,635
 
Plan: Primal/Paleo Atkins
Stats: 197.5/126/132 Female 63
BF:19.4%
Progress: 109%
Location: Baltimore, MD
Default

Hi Patricia-
I'm the buddy that Liz mentioned earlier. I've been away from the computer most of the day, so just saw her post.

I agree that the science is not settled. I once worked for one of the top cholesterol specialists in the U.S. and have watched the "best and latest" information change repeatedly.

Initially, docs focused on TC alone. Then a changing cascade of information came along re: LDL, HDL, ApoB and triglycerides. Over time the ranges considered normal and those considered dangerous also changed.

When the VAP test came along, many considered it the latest and best because it gave you your particle size. The theory is/was that even if LDL is elevated, if the LDL particles are of the large "fluffy" variety they do not pose the danger that small sticky particles do as those are able to infiltrate the artery wall. This, however, is no longer the leading edge thinking.

Many researchers now think that what truly contributes to CAD is the number of particles one has. Dr. Thomas Dayspring and Dr. Peter Attia (both of whom you can listen to on YouTube and whose articles and/or blogs can be accessed online) plus a # of leading cardiologists take this position. Their explanation is thus: LDL particles are the carriers of cholesterol&fats. Picture them as little boats moving thru your arteries. It matters not how much cholesterol is in each boat -- but HOW MANY BOATS THERE ARE, because the more there are the greater risk of their bumping into artery walls and causing damage. Dayspring (a top cardiologist) has said repeatedly that he considers ones particle number to be the best tool for assessing a patient's cardio health.

I lost my excess pounds by doing Atkins, but also found that my TC & LDL went up. On the good side, my HDL was excellent for the first time in my life and my trigs dropped to the basement. My VAP showed that my LDL particles were of the large, fluffy variety so I said no worries, right?

But after reading Dayspring, etal I learned of patients who had felt safe with a profile like mine but turned out not to be, so I had an NMR done. My first particle count 1493 but bounced higher on repeated tests. Then, in an effort to lose a few more pounds, I focused on going "keto", raising the % of fat in my diet and also introduced coconut oil. Subsequent testing done at Health Diagnostic Labs (1 # of docs think they are the best), gave particle number values of 2131 and 2843, this BTW also accompanied by rises in TC, LDL, & ApoB. Scary.

Luckily I read on another site of a person's similar experience after adding liberal quantities of coconut oil to their diet & have since found a few more similar accounts. So I eliminated the coconut oil and stopped being so liberal with butter & olive oil. I skimmed some of the fat off of broths and soups. I just stopped operating as though high fat is the answer. I know many people think it is, but it isn't for me -- and that doesn't mean I've become a lowfat person by any means -- just not as wildly liberal as I once was. And guess what -- the next test had my particle count down to 1155! All other values improved remarkably as well. My HDL stayed optimal and trigs stayed low b/c I still eat relatively low carb. In maintenance I find I can eat 100 g or so of carbs but when I was actively losing I had to keep them much lower.

So carefully assessing your dietary fat might make a difference.
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  #12   ^
Old Tue, Jan-27-15, 15:11
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,863
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
Default

Great posting Jan!
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  #13   ^
Old Tue, Jan-27-15, 15:23
JEY100's Avatar
JEY100 JEY100 is online now
Posts: 13,431
 
Plan: P:E/DDF
Stats: 225/150/169 Female 5' 9"
BF:45%/28%/25%
Progress: 134%
Location: NC
Default

Great to hear from you on this topic, Jan. Hope you are doing well.
I am with you on your decision not to load up on "extra" fats, though for some other reasons too. I didn't re-do my NMR, but my regular blood test LDL total count went back to "normal" by conventional lab ranges.

Here is another good summary of this concern over lipid values, links to various expert options, and what this dietician decided to do about it. A good blog post from Franziska Spritzler, RD. ( a bit long, with charts, photos, so can't copy it)

http://www.lowcarbdietitian.com/blo...-own-experience

Last edited by JEY100 : Tue, Jan-27-15 at 16:57.
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  #14   ^
Old Tue, Jan-27-15, 15:23
Liz53's Avatar
Liz53 Liz53 is offline
Senior Member
Posts: 6,140
 
Plan: Mostly Fung/IDM
Stats: 165/138.4/135 Female 63
BF:???/better/???
Progress: 89%
Location: Washington state
Default

Here is a link to dietician Franziska Spritzler's web site where she discusses how higher fat led her to more particles. This may be the article Jan referenced?

http://www.lowcarbdietitian.com/blo...-own-experience

ETA: I see JEY beat me to it.
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  #15   ^
Old Tue, Jan-27-15, 16:03
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,863
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
Default

Quote:
On the other hand, we also know that many people with high LDL-C and high LDL-P never have CHD.

Good posting! Just excerpting this sentence it means:

Those two factors are connected to a 3rd factor (or others) which we don't know. Could be genetics or something else entirely. Smoking, drinking, driving without a seatbelt (okay, probably not :lol.

I should probably get a coronary calcium scan, but I don't have a strong history of heart disease in my family. Our issue is blood clots.

Last edited by Nancy LC : Tue, Jan-27-15 at 19:59.
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