Salt accused of causing diabetes : LC Research/Media Forum : Active Low-Carber Forums

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Mon, Sep-18-17, 03:36

teaser

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Salt accused of causing diabetes

Quote:

Sodium (salt) intake is associated with a risk of developing type 2 diabetes

Sodium intake may be linked to an increased risk of developing both type 2 diabetes (T2D) and Latent Autoimmune Diabetes in Adults (LADA) says new research being presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD) in Lisbon, Portugal (11-15 Sept).

The main source of sodium in the diet is through salt. Salt (sodium chloride) is 40% sodium, so that for every 2.5g of salt consumed, 1g is sodium. Previous research* has suggested that excessive salt consumption may increase the risk of developing T2D, possibly through a direct effect on insulin resistance, and/or by promoting high blood pressure and weight gain.

LADA is a form of type 1 diabetes (T1D) in which the insulin-producing cells in the pancreas are destroyed by the body's own immune system, but unlike typical T1D it develops very slowly, sometimes over a period of years. This, together with it appearing in later in adulthood, can lead to it being mistakenly diagnosed as T2D.

This study was conducted by Dr Bahareh Rasouli of The Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden, and colleagues from institutions in both Sweden and Finland, and aimed to discover whether there is a link between sodium intake and the risk of developing T2D or LADA.

The team used data from a Swedish population-based study of risk factors for LADA and T2D, and compared the 355 and 1136 cases of each respectively with a matched group of 1379 individuals from the wider population acting as controls. Dietary intake was recorded using a food questionnaire and used to calculate the daily consumption of calories, nutrients, and sodium. The influence of genetics on diabetes risk was also considered, with patients being divided into 'high risk or 'other' according to their HLA genotype. Adjustments were made to account for differences in risk factors including age, sex, BMI, smoking, physical activity, family history of diabetes, alcohol, total energy, and potassium intake.

The study found that sodium intake was associated with an average 43% increase in the risk of developing T2D for each extra gram of sodium (equivalent to 2.5 extra grams of salt) consumed per day. When dividing participants into three groups of sodium consumption (low under 2.4g; medium 2.4-3.15g; high above 3.15g), the group with highest consumption had a 58% higher risk of developing T2D compared with the lowest consumption group. However, since salt is only 40% sodium by weight, for actual salt consumption the low consumption group is 6.0 grams and under; the medium consumption group is 6.0-7.9g; and the high group is above 7.9 grams per day.

The effect of sodium intake on the risk of developing LADA was even greater, with a 73% rise for each gram of sodium consumed per day. Those LADA patients with high risk HLA genotypes whose sodium intake was classed as 'high' (over 3.15 g/day) were almost four times more likely to develop the disease than those consuming the lowest (under 2.4g/day).

The authors conclude: "We confirm an association between sodium intake and type 2 diabetes" and that "high sodium intake may be a risk factor for LADA, especially in carriers of high risk HLA genotypes." They suggest that "These findings may have important implications in the primary prevention of diabetes with adult onset."

https://www.sciencedaily.com/releas...70914210621.htm

Quote:

Those LADA patients with high risk HLA genotypes whose sodium intake was classed as 'high' (over 3.15 g/day) were almost four times more likely to develop the disease than those consuming the lowest (under 2.4g/day).

Four times as likely sounds like a strong correlation, good enough that causation is likely. But I once saw a study showing omega 6 fatty acids correlated with six times as much glaucoma, but only after correcting for a number of things, without the corrections, there was very little correlation. Also if there's a very high correlation of salt with something else, say a generally poor diet, the correlation to salt can be non-random without being causative. For years I never salted my food, all that means is that homemade food can't compete with commercial food.