Originally Posted by teaser

There were some missteps in studying ketogenic diets in mice where the ketogenic diets were choline deficient, leading to fatty liver. So, do you like eggs, liver?

Free fatty acids provide material for triglyceride storage in the liver, so it's not that weird if a diet or approach, low carb, fasting, that increases free fatty acids leads to an elevation of liver fat, I guess the question is, what usually prevents this? Something that can happen with type II diabetics when they go on insulin initially, their liver fat reduces. This is thought to be due to more effective fat trapping in subcutaneous fat, the liver is exposed to lower free fatty acid levels, especially after a meal when it's busy dealing with excess carbohydrate. People talk a lot about de novo synthesis of fatty acids from carbohydrate, but by far the most efficient way to fatten the liver is with preformed free fatty acids so that all that's really needed is re-esterification/triglyceride synthesis.