Wed, Dec-01-10, 07:55
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Senior Member
Posts: 15,075
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Plan: mostly milkfat
Stats: 190/152.4/154
BF:
Progress: 104%
Location: Ontario
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ScienceDaily also reported on this.
http://www.sciencedaily.com/release...01130171955.htm
I was hoping they'd have some more information, whether or not the mice were obese to start with, for instance. Mice are generally leaner than humans, maybe that would have an effect on the response to dieting down by ten or fifteen percent.
This article in the "relateds" is interesting;
Quote:
Changing To A Low-Fat Diet Can Induce Stress
Using a variety of standard measures of mouse behavior, researchers acclimated mice to either high-fat (HF) or high-carbohydrate (HC) diets, abruptly replaced those diets with standard chow, and observed behavioral changes. The brains of the mice were also examined for increases in corticotrophin releasing factor (CRF) levels which can indicate high stress levels.
Writing in the article, Tracy L. Bale, Ph.D., states, "Our behavioral, physiologic, biochemical, and molecular analyses support the hypothesis that preferred diets act as natural rewards and that withdrawal from such a diet can produce a heightened emotional state." Once deprived of their preferred diet, mice would overcome their natural aversion to bright environments to obtain the HF foods, even when standard food was available.
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The abstract for this study;
Quote:
Decreases in Dietary Preference Produce Increased Emotionality and Risk for Dietary Relapse
Background
Obesity is a modern health epidemic, with the overconsumption of highly palatable, calorically dense foods as a likely contributor. Despite the known consequences of obesity, behavioral noncompliance remains high, supporting the powerful rewarding properties of such foods. We hypothesized that exposure to preferred diets would result in an amelioration of stress responsivity via activation of reward pathways that would be reversed during dietary withdrawal, increasing the risk for relapse and treatment failure.
Methods
Mice were exposed to preferred diets high in fat or carbohydrates for 4 weeks and then were withdrawn to house chow. Behavioral, physiologic, and biochemical assays were performed to examine changes in stress and reward pathways.
Results
These studies revealed significant changes in arousal and anxiety-like behaviors, limbic corticotropin-releasing factor expression, and expression of reward-related signaling molecules in response to the highly preferred high-fat diet that was reversed by withdrawal. In a dietary-reinstatement model, mice withdrawn from the high-fat diet endured an aversive environment to gain access to the preferred food.
Conclusions
Exposure to a highly preferred diet high in fat reduces stress sensitivity, whereas acute withdrawal from such a diet elevates the stress state and reduces reward, contributing to the drive for dietary relapse.
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At least two ways to look at this. (If this applies to humans, and not just mice.) Stress increases preference for fat, according to the Telegraph story. So stress makes fat make us fat. Or, fat is soothing, and at some increased level of fat intake as a percentage of diet, appetite might actually be reduced. The fat doesn't make us fat, we just have an increased appetite for fat that isn't satisfied by protein or carbohydrate.
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