Thu, Sep-07-17, 18:49
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Senior Member
Posts: 15,075
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Plan: mostly milkfat
Stats: 190/152.4/154
BF:
Progress: 104%
Location: Ontario
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Thanks for posting.
Quote:
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation.
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I remember a thread, this probably in my first year or two on the forum, about Dwarf Snell mice, they burn much more fat vs. glucose compared to wild-type mice, and have longer lifespans. Also the methionine-restricted mice--there was a study showing a greater proportion of their energy coming from mitochondrial respiration vs. glycolysis. There are also studies showing that methionine restriction reduces fat trapping by adipocytes, that could increase availability of fat for oxidation. And there's the very obvious periods of increased fat oxidation that comes with intermittent fasting, increased fat oxidation-->increased longevity seems to be a fairly constant theme.
Some of those things the ketogenic animals did better with, like grip strength, time to explore novel objects--it would be interesting to see what would happen, towards the end of the lifespan, if some control animals were switched to the ketogenic diet. How much is the result of the extended period on the diet, how much just the effect of being currently in ketosis?
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