Thanks for answering, I'm not sure I got that from Bikman's presentation, I guess I'll have to watch it again. Interesting individual results. What sort of protein intake and ketone level are we talking about here? There might be a difference between say 50 or 70 grams of protein and 100, but not between 100 and 130, for instance. There's a lot of clinical/anecdotal evidence out there that protein does affect ketosis, I belong to a facebook page that covers keto for neurological purposes, lots of people there are using blood ketone meters.

Bikman did go into detail illustrating the results from his study showing how the I:G ratio changed for different diets and how increased protein had a much less relative impact on those with a low I:G ratio. This is around the 15:00 portion of his presentation. The point he made is that the low I:G is more representative of a fasted state, so the benefits are insulin sensitivity, autophagy, lipolysis, and brown adipose tissue activation. Later, starting at about 19:00 to 20:00 he discusses how protein compounds the I:G ratio and effect for those following SAD compared to those following low carb. It's a very good presentation through the end, as he touches on many things we've discussed on this forum, and his remarks are based on his research. Again for me, I've been able to increase protein from under 100 grams per day, varying window of about 75-100, where I could measure blood ketones to 128-136 grams per day without a significant change in my blood ketones. To be accurate, there are some days where I'm around 100, and most others above 120. Since I'm in my 67th year, I'm taking advantage of the claims that increasing protein as we age is beneficial. This increase has not noticeably impacted the presence of ketones. As mentioned, I have not gorged on protein to test that impact and don't plan to, as I eat to satiety, and protein and fat get me there fast.

Edited to add: I'm wondering how much age and physical condition can influence protein's role in glucose production that negatively impacts ketone production; however, I believe Bikman's contention is correct in that many who notice protein limits ketones may not be starting from a place that is truly low carb. I try to stay under 20 grams of carbs per day, and I'm sure that has a beneficial influence on protein impact as well.

Here's another podcast on upping protein levels:
https://www.biohackerslab.com/ep23-...tuart-phillips/
Same conclusions especially about upping protein as you age. I am 69 and have increased my protein over the past few weeks. Marty Kendall has written about how high protein diets have the greatest satiety effect. I have noticed that my overall calorie intake is down while my protein is up to around 28% of total calories. I'm enjoying eating this way and plan to continue it for the foreseeable future. My takeaway from it all was that by upping protein I am either preventing or at least slowing down the muscle loss that accompanies aging (sarcopenia).

Jean, excellent discussion with Phillips. Thanks for the link. BioHackers is a good source.

A valuable benefit!

I noticed from years of rescuing cats that as they age, they need MORE nutrients because their digestion is no longer working at peak efficiency. Probably works that way for us: which means we aren’t increasing protein so much as compensating for what is no longer reaching our cells as efficiently.