Active Low-Carber Forums
Atkins diet and low carb discussion provided free for information only, not as medical advice.
Home Plans Tips Recipes Tools Stories Studies Products
Active Low-Carber Forums
A sugar-free zone


Welcome to the Active Low-Carber Forums.
Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

Go Back   Active Low-Carber Forums > Main Low-Carb Diets Forums & Support > Low-Carb Studies & Research / Media Watch > LC Research/Media
User Name
Password
Register FAQ Members Calendar Mark Forums Read Search Gallery My P.L.A.N. Survey


Reply
 
Thread Tools Display Modes
  #1   ^
Old Thu, Jun-29-17, 11:13
RawNut's Avatar
RawNut RawNut is offline
Lipivore
Posts: 1,170
 
Plan: Very Low Carb Paleo
Stats: 270/185/180 Male 72 inches
BF:
Progress: 94%
Location: Florida
Default Longer Life Through Lower Blood Sugar

Many experiments and studies on life extension have found the interesting and important result that lowering blood glucose (blood sugar) and/or restricting dietary carbohydrates means longer life. This has been found using several different lab animals and in humans as well. Itís possible to have longer life through lower blood sugar.

Acarbose

Acarbose is an anti-diabetic drug that works by inhibiting enzymes in the gut that break down carbohydrates to glucose, and therefore less glucose is absorbed.

Male mice that were fed acarbose lived 22% longer than controls, although the female mice lived only about 7% longer.



A lifespan increase of 22% is large, among the longer lifespan extensions seen with other interventions, comparable to rapamycin and a larger increase than fat-tissue insulin receptor knockout. Acarbose reduced fasting insulin in male mice but not in females, which may account for the difference in lifespan extension.

IGF-1 was decreased in both sexes, and fibroblast growth factor 21 (FGF21) was increased, and both of these hormonal changes could be involved in life extension.

In humans with type 2 diabetes, long-term acarbose treatment was associated with a huge 50% decrease in the risk of cardiovascular events such as heart attack and stroke. Importantly, the risk reduction was associated with a decrease in postprandial hyperglycemia, or a rise in blood sugar after eating.

A meta-analysis of acarbose found similar large reductions in CVD events.

Since dietary carbohydrates, especially grains, sugar, and starches, are the primary determinant of blood sugar, why not just cut carbohydrates instead?

Metformin

Metformin is the most prescribed anti-diabetic drug, and it lowers blood sugar and insulin. Similar large reductions in death rates have been found with metformin use, so much so that diabetics using metformin may outlive non-diabetics who donít use it.

Would cutting carbohydrates cause the same life extension and anti-aging as metformin?

An argument against that is that diabetics taking metformin may live longer than non-diabetics who donít take it. Therefore, metformin may be causing a real anti-aging effect.

An argument for it is that most non-diabetics eat large amounts of carbohydrates, with the average American eating about 50% of his or her calories as carbohydrate. And among average people, Dr. Joseph Kraft showed that large numbers, perhaps up to 80%, have some degree of impaired glucose tolerance, i.e. theyíre insulin resistant.

If metformin increased lifespan in animals or people who ate little or no carbohydrates, that would be convincing, but to my knowledge, it has not.

Glucosamine

Glucosamine is an over-the-counter supplement commonly taken for arthritis and joint pain. Glucosamine extends lifespan in mice through
an induction of mitochondrial biogenesis, lowered blood glucose levels, enhanced expression of several murine amino-acid transporters, as well as increased amino-acid catabolism. Taken together, we provide evidence that GlcN [glucosamine] extends life span in evolutionary distinct species by mimicking a low-carbohydrate diet. [My emphasis.]

Glucosamine impairs glycolysis (glucose metabolism) and therefore lowers blood glucose levels.

Glucosamine also activates autophagy, the cellular self-cleansing process that retards aging, and inhibits mTOR, the cellular growth engine that accelerates aging.

In humans, use of glucosamine is associated with an 18% lower death rate.

Again, if glucosamine mimics a low-carbohydrate diet, why not just eliminate the middleman and refrain from eating carbohydrates?

Ketones

Fasting, eating a very low amount of carbohydrates (usually less than 50 grams daily), or taking ketone supplements or MCT oil raises the amount of molecules known as ketones in the bloodstream. Increased ketones mimic the effects of food restriction by lowering blood glucose and insulin.

While ketone supplements are generally beneficial in my opinion, if you cut the carbohydrates, albeit radically, youíre in ketosis (producing ketones) and presumably extending your lifespan and fighting aging by doing so.

Glucose

Feeding glucose to the worm C. elegans shortens its lifespan.

Restricting glucose extends its lifespan.

When carbohydrates are digested, they become glucose inside the body, since most carbohydrates are just long chains of glucose. (Sugars may incorporate other molecules, such as fructose and galactose.)

So why not just restrict carbohydrates?

Multiple lines of evidence lead to carbohydrate restriction

As weíve seen from the studies above, multiple lines of evidence lead to the conclusion that restricting carbohydrates and thus preventing high blood glucose, whether spikes in it or a higher average glucose, leads to longer life.

These same lines of evidence lead to the conclusion that carbohydrates can promote aging and shorten life.

Note that some carbohydrates, namely complex carbohydrates found in non-starchy vegetables, donít raise blood sugar much if at all.

The foods that contain abundant carbohydrates and increase blood glucose are the ones to restrict or eliminate, and they include grains (wheat, rice, corn, etc.), sugar, and starchy tubers such as potatoes.

Someone who is very insulin sensitive may not be harmed much by carbohydrates. These people include athletes and other lean people who exercise or labor at physically demanding jobs.

Anyone else, and that includes most people, would likely see a big improvement in health by restricting carbohydrates.

http://roguehealthandfitness.com/lo...er-blood-sugar/
Reply With Quote
Sponsored Links
  #2   ^
Old Thu, Jun-29-17, 11:57
GRB5111's Avatar
GRB5111 GRB5111 is offline
Posts: 1,842
 
Plan: Ketogenic (LCHFKD)
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

Good summary and all the questions posed are considerations everyone should take seriously. If the same results can be achieved by managing diet, wouldn't that approach also be the most sensible, cost effective, and healthier decision?
Reply With Quote
  #3   ^
Old Sat, Jul-01-17, 05:28
WereBear's Avatar
WereBear WereBear is offline
Posts: 9,910
 
Plan: Epi-Paleo/IF
Stats: 220/162/150 Female 67
BF:
Progress: 83%
Location: USA
Default

Quote:
Originally Posted by GRB5111
Good summary and all the questions posed are considerations everyone should take seriously. If the same results can be achieved by managing diet, wouldn't that approach also be the most sensible, cost effective, and healthier decision?


Especially since "cutting out the middleman" works on the problem directly, and can have even more (as yet not known) benefits.

It's kind of like:

"Pouring gasoline on the fire makes it flare up!"

"If I add water to that stream of liquid the fire is less."

"You are a genius! Let's do that!"

"We could not put gasoline on it."

"Can't! Lipid hypothesis stops us!"

Last edited by WereBear : Sat, Jul-01-17 at 05:33.
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -6. The time now is 04:33.


Copyright © 2000-2017 Active Low-Carber Forums @ forum.lowcarber.org
Powered by: vBulletin, Copyright ©2000 - 2017, Jelsoft Enterprises Ltd.