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  #76   ^
Old Fri, Sep-28-18, 13:50
Luckyk26's Avatar
Luckyk26 Luckyk26 is offline
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For what it's worth, I've been doing a lot of research on CBD oil. It started because my vet suggested it for my dog's seizures. However, they are having great success with depression and autism and all kinds of things with very little side effects. I have no personal experience with it, just thought I'd throw that out there. Hope I don't offend anyone - it wasn't my intention.
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  #77   ^
Old Fri, Sep-28-18, 13:53
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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https://therenegadepharmacist.com/d...ilar-diet-soda/



Quote:

Excitotoxins are shown to freely penetrate certain brain regions and rapidly destroy neurons by hyperactivating the NMDA subtype of Glu receptor in studies.

Cravings for more coke are explained by the release of two neurotransmitters in the brain, dopamine and glutamate.

Caffeine and aspartame increases dopamine levels as shown in various studies.

Aspartic acid taken in its free form (unbound to proteins), significantly raises the blood plasma level of aspartate and glutamate.

Researchers say glutamate is more essential to addiction than dopamine. Source: Phenotype Offers New Perception on Cocaine The Scientist Date: 21 Jan 2002

http://www.ncbi.nlm.nih.gov/pubmed/7854587


this is misleading as the study above , in which the real thing is used does NOT increase the blood plasma.

caffeine and aspartame increases dopamine.
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  #78   ^
Old Fri, Sep-28-18, 13:59
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Quote:
Originally Posted by Luckyk26
For what it's worth, I've been doing a lot of research on CBD oil. It started because my vet suggested it for my dog's seizures. However, they are having great success with depression and autism and all kinds of things with very little side effects. I have no personal experience with it, just thought I'd throw that out there. Hope I don't offend anyone - it wasn't my intention.



Thanks for your input. No offense. It is legal in this state.

Will try to research it more. It has not come up in any thing yet, but it could be because it has not been an accepted option for so many reasons.

THe only thing I know is that Dr AMen is not a supporter of smoking the leaves. His take is that the effect is not localized enough: hurting some areas and helping some areas of the brain at the same time.

Perhaps more information is now available.
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  #79   ^
Old Fri, Sep-28-18, 14:05
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Luckyk26 Luckyk26 is offline
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I would assume smoking would increase the risks of other health risks too - although I could be wrong. This was a good article because it explains how it helps the brain function properly. https://cannabismd.com/health/autis...nd-mild-autism/

My boyfriends daughter (now son) has autism, aspergers, is transgender, has an eating disorder and is suicidal. I know the feeling of wanting to do absolutely everything and feeling powerless. Hopefully something helps.
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  #80   ^
Old Fri, Sep-28-18, 14:57
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Thank you. Trying to help the brain is a struggle. Too few experts know what they are talking about. So I look to Dr AMen and work from there.

Found this:

Quote:
Using CBD Oil for Anxiety: Does It Work?
How it works
What the research says
Side effects
Is it legal?
Overview
Early research shows promising signs that a product made from cannabis known as cannabidiol (CBD) oil may help relieve anxiety. CBD is a type of cannabinoid, a chemical found naturally in marijuana and hemp plants. Unlike tetrahydrocannabinol (THC), another type of cannabinoid, CBD doesn’t cause any feelings of intoxication or the “high” you may associate with cannabis. Learn more about the potential benefits of CBD oil for anxiety, and whether it could be a treatment option for you.

How CBD oil can help anxiety
CBD oil is thought to work with a brain receptor called CB1. Receptors are tiny proteins attached to your cells that receive chemical signals from different stimuli and help your cells respond.

The exact way CBD affects CB1 is not fully understood. However, it’s thought that it alters serotonin signals. Serotonin is one of your body’s chemicals and plays a role in your mental health. Low serotonin levels are common in depression. Not having enough serotonin can also cause anxiety in some people.

The conventional treatment for low serotonin is prescription selective serotonin reuptake inhibitors (SSRIs). Zoloft and Prozac are both SSRIs. CBD, for some people, may be an alternative to SSRIs for anxiety management. However, you should talk to your doctor before making changes to your treatment plan.

Research and evidence
Several studies point to the potential benefits of CBD for anxiety. For generalized anxiety, the National Institute on Drug Abuse says that CBD has been shown to reduce stress in animal studies. Study subjects were observed as having lower behavioral signs of anxiety. Their physiological symptoms of anxiety, like increased heart rate, also improved.

Studies have also shown some benefits for other forms of anxiety, such as social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD). CBD may also help treat anxiety-induced insomnia.

In 2011, a human study on CBD and its effects on SAD was published in the Journal of Psychopharmacology. Participants were given either an oral dose of 400 milligrams of CBD or a placebo. The results showed that those who took the CBD dose experienced overall reduced anxiety levels.

On the other hand, a 2017 comprehensive review of CBD studies in psychiatric disorders found inconclusive results. According to the authors, there isn’t enough evidence to claim CBD as a treatment for depression. However, the authors do note positive results for anxiety disorders. Based on their review, more human tests are needed to better understand how it works, what ideal dosages should be, and if there are potential side effects or hazards.

CBD has also been studied in other neurological disorders. A 2016 study found some antipsychotic benefits of CBD in schizophrenia. The authors indicated a preference for CBD over antipsychotic drugs, which are known to cause significant debilitating side effects.

CBD oil side effects
CBD is generally considered safe. However, some people who take CBD may experience side effects, including:

gastrointestinal discomfort
sleeping difficulties
mood changes
dry mouth
dizziness
fatigue
You shouldn’t stop taking any medications you’re already using without talking to your doctor first. Using CBD oil may help your anxiety, but you could also experience withdrawal symptoms if you suddenly stop taking your prescription medications. Symptoms of withdrawal include:

irritability
dizziness
nausea
fogginess
Is CBD oil legal?
CBD oil isn’t legal everywhere. In the United States, some states allow it for only specific medical purposes and some don’t. You may need to get a license from your doctor to be able to use CBD. If cannabis is approved for medical use in your state, you may be able to purchase CBD oil online or in special cannabis stores or clinics. As research on CBD continues, more states may consider the legalization of cannabis products.

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  #81   ^
Old Fri, Sep-28-18, 15:51
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Quote:
Blueberry Headband
This is another hybrid strain, with a THC content of 18-26% and a CBD content of under 1.0%.

It’s perfect for those looking to stimulate their creative sides, and will also give you a serious boost of energy. It will also help you to be more social, which means it’s awesome for those with Autism.


https://cannabismd.com/health/autis...nd-mild-autism/
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  #82   ^
Old Fri, Sep-28-18, 17:28
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Need to compare this to Dr AMen's section on temporal lobe ADD


Quote:
Endocannabinoids can also play a role in excitation of the neuronal networks, thus having effect on the quality of a seizure. Previous studies have documented deficiencies in endocannabinoids in temporal lobe epilepsy patients as well as a rise in anandamide concentrations post seizures in mice, suggesting an antiseizure activity profile.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473390/
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  #83   ^
Old Fri, Sep-28-18, 17:33
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Quote:

THC is a partial agonist at both CB1 and CB2 receptors and achieves its psychoactive properties likely through modulation of gamma-aminobutyric acid (GABA) and glutamine. THC seems to possess antiseizure activity but may be a proconvulsant in certain species.1


Dr AMen discusses GABA-- find pages in Healing ADD book


Quote:
The authors summarized the finding that a CBD dose of 200 mg to 300 mg daily was safely administered over a short period. The only reasonable conclusion made was that the efficacy of CBD use could not be confirmed, but the rate of adverse reactions in each of the studies was low over a short period.


Quote:
results from mice and pig models demonstrate that CBD can reduce the density of necrotic neurons and modulate cytokine release.


Quote:
Tumor growth in both the THC and CBD groups was significantly reduced.

Last edited by Ms Arielle : Fri, Sep-28-18 at 18:00.
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  #84   ^
Old Fri, Sep-28-18, 18:25
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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http://n.neurology.org/content/90/15_Supplement/P3.318

Quote:
Cannabidiol Based Medical Cannabis in Children with Autism- a Retrospective Feasibility Study (P3.318)
ADI ARAN, Hanoch Cassuto, Asael Lubotzky
First published April 9, 2018,

Abstract
Objective: This retrospective study assessed safety, tolerability and efficacy of cannabidiol (CBD) based medical cannabis, as an adjuvant therapy, for refractory behavioral problems in children with ASD.

Background: Anecdotal evidence of successful cannabis treatment in children with autism spectrum disorder (ASD) are accumulating but formal studies are lacking.

Design/Methods: Sixty children with ASD (age = 11.8± 3.5, range 5.0–17.5; 77% low functioning; 83% boys) were treated with oral CBD and tetrahydrocannabinol (THC) at a ratio of 20:1. The dose was up-titrated to effect (maximal CBD dose − 10mg/kg/d). Tolerability and efficacy were assessed using a modified Liverpool Adverse Events Profile, the Caregiver Global Impression of Change (CGIC) scale, the Home Situations Questionnaire–Autism Spectrum Disorder (HSQ-ASD) and the Autism Parenting Stress Index (APSI).

Results: Following the cannabis treatment, behavioral outbreaks were much improved or very much improved (on the CGIC scale) in 61% of patients. The anxiety and communication problems were much or very much improved in 39% and 47% respectively. Disruptive behaviors, were improved by 29% from 4.74±1.82 as recorded at baseline on the HSQ-ASD to 3.36±1.56 following the treatment. Parents reported less stress as reflected in the APSI scores, changing by 33% from 2.04±0.77 to 1.37±0.59. The effect on all outcome measures was more apparent in boys with non-syndromic ASD. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%).

Conclusions: This preliminary study support the feasibility of CBD based medical cannabis as a promising treatment option for refractory behavioral problems in children with ASD. Based on these promising results, we have launched a large, double blind, placebo controlled cross-over trial with 120 participants (NCT02956226).

Study Supported by: N/A

Disclosure: Dr. ARAN has nothing to disclose. Dr. Cassuto has nothing to disclose. Dr. Lubotzky has nothing to disclose.

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  #85   ^
Old Fri, Sep-28-18, 18:31
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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April 10, 2018; 90 (15 Supplement) APRIL 22, 2018
Exposure-Response Analysis of Cannabidiol (CBD) Oral Solution for the Treatment of Lennox–Gastaut Syndrome (P1.271)
Gilmour Morrison, Maria Luisa Sardu, Christian Hove Rasmussen, Kenneth Sommerville, Claire Roberts, Graham E. Blakey
First published April 9, 2018,


Quote:
Results: Both dose levels showed a separation between the change from baseline of drop seizures for active treatment compared to placebo after approximately 15 days. At the 20mg/kg dose, a higher proportion of patients achieved ≥75% and 100% seizure reduction. Logistic regression analysis of the drop seizure responder rate revealed a significant (p<0.01) positive correlation with the AUC for CBD and 7-OH-CBD exposures. Predicted probability of response was in the order of 80% for the highest AUCs. For several AEs, logistic regression found a significant positive correlation between the probability of a subject having at least one AE and the respective AUC of the analytes.

Conclusions: Results suggest that the observed efficacy and safety responses are directly related to CBD and 7-OH-CBD exposure. Add-on CBD could represent a viable treatment for an otherwise pharmacoresistant condition.

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  #86   ^
Old Fri, Sep-28-18, 18:36
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Quote:

In a seminal article published in 1943, Leo Kanner1 described cases of school-aged children with notable impairments in social interaction and the presence of somewhat atypical, often repetitive, behaviors, which he characterized as “inborn autistic disturbances of affective contact.” While the term “autism” was coined by Bleuler in the early 1900s in connection with schizophrenia, it was Kanner (and then Asperger) who laid the foundation for autism being considered a neurodevelopmental disorder. Not until 1980, however, did autism become a formal clinical diagnosis (American Psychiatric Association, DSM-III, 1980). Since then, the term has evolved to encompass a wide range of cognitive abilities, comorbidities, and developmental stages known collectively as autism spectrum disorder (ASD), and increased awareness and broadening of this spectrum have been accompanied by a rapid rise in prevalence, now estimated to be 1:68 children.2


http://n.neurology.org/content/88/14/1303

Last edited by Ms Arielle : Sat, Sep-29-18 at 07:35.
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  #87   ^
Old Mon, Oct-01-18, 07:29
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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More on MAIOs ---one source said these are no longer in favor as the it also interferes with other biochemicals that cause side effects.


Other sources to look at
http://n.neurology.org/
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