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Old Tue, Jun-05-18, 09:51
RawNut's Avatar
RawNut RawNut is offline
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Plan: Very Low Carb Paleo
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Location: Florida
Default Modified ketogenic diet in lymphoma: A case series in the Veteran Affairs Pittsburgh

Quote:
Background: Cancer cells preferentially use glucose due to mitochondrial dysfunction. Ketogenic diets preferentially feed normal cells while starving cancer. There are no human studies on ketogenic diets in lymphomas or leukemia.

Methods: Three lymphoma patients began the modified ketogenic diet. We provided dietary advice, limited daily carbohydrate to 20-40 grams, omitted sweets and starches. Data on their history, dietary course and clinical outcomes are presented.

Results: Case 1: 52 year old male with mycosis fungoides was on UVB light and topical steroid treatment for a year. Pruritic erythema covered 90% of his body, including the scalp, legs, arms, chest and entire back. Frontal scalp, medial eyebrows had patchy alopecia plus he had eyeball pain and daytime sweating. Weight was 255 lbs. Four months later he lost 22 lbs (232 lb), and eyeball pain was gone. Arm and back erythema faded. 7 months later, his back was erythema free. 15 months later, at 206 lb (49 lb wt. loss) his eyebrows normalized, with mild erythema left over parts of his face.

Case 2. 80 y.o male with CLL/SLL progressed on Bendamustine + Rituximab BR and transformed into prolymphocytic lymphoma. He lost 31 lb. (17% of baseline), had bilateral leg edema, pleural effusions and increasing adenopathy on imaging scans. We held chemotherapy and he started the diet. A week later he lost 12 more lbs. but was more energetic and edema resolved. Concerned about the weight loss, he added low glycemic fruits to his diet. Weight improved and 2 months later he resumed chemotherapy, recovering to baseline weight by 1 year. Two years later he is disease free on maintenance Rituximab.

Case 3. 73 y/o male with MALT gastric lymphoma and Stage 3 mantle cell lymphoma had a partial response after 6 cycles of BR chemotherapy. Weighing 216 lb, BMI 28.6, he began the diet at cycle 4. Six months after chemotherapy he lost 22 lbs (11%) and PET CT scans were cancer free. He is disease free 2 years later.

Conclusions: Ketogenic diets in human lymphomas appears well tolerated and can improve symptoms, quality of life, and possibly limit tumors. Ketogenic diets may reverse the weight loss seen in terminal cancer patients with cachexia.


http://ascopubs.org/doi/abs/10.1200...15_suppl.e24222
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