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  #1   ^
Old Thu, Feb-09-06, 10:55
Zuleikaa Zuleikaa is offline
Finding the Pieces
Posts: 17,049
 
Plan: Mishmash
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Default Vitamin D and PCOS

Thought this would be relevant here.

Vit D_PCOS

Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome.
Panidis D, Balaris C, Farmakiotis D, Rousso D, Kourtis A, Balaris V, Katsikis I, Zournatzi V, Diamanti-Kandarakis E.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.
Thys-Jacobs S, Donovan D, Papadopoulos A, Sarrel P, Bilezikian JP.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Decreased bioavailability of vitamin D in obesity1,2,3
Jacobo Wortsman, Lois Y Matsuoka, Tai C Chen, Zhiren Lu and Michael F Holick
http://www.ajcn.org/cgi/content/full/72/3/690

Inadequate vitamin D status: Does it contribute to the disorders comprising syndrome ‘X’?
Boucher, B. J.1
http://<br /> http://www.ingentaco...53dc152d8667e07

Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults
Earl S. Ford, MD, MPH1, Umed A. Ajani, MBBS, MPH1, Lisa C. McGuire, PHD1 and Simin Liu, MD, SCD2,3
http://<br /> http://care.diabetes.../full/28/5/1228

Hypovitaminosis D is associated with insulin resistance and ß cell dysfunction1,2,3
Ken C Chiu, Audrey Chu, Vay Liang W Go and Mohammed F Saad
http://<br /> http://www.ajcn.org/...stract/79/5/820

Acanthosis nigricans associated with insulin resistance : pathophysiology and management.
Hermanns-Le T, Scheen A, Pierard GE.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Vitamin D binding protein in endometriosis.
Ferrero S, Gillott DJ, Anserini P, Remorgida V, Price KM, Ragni N, Grudzinskas JG.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells.
Du H, Daftary GS, Lalwani SI, Taylor HS.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.
Gabant P, Forrester L, Nichols J, Van Reeth T, De Mees C, Pajack B, Watt A, Smitz J, Alexandre H, Szpirer C, Szpirer J.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

1,25-Dihydroxyvitamin D3 restores fertility of vitamin D-deficient female rats.
Kwiecinksi GG, Petrie GI, DeLuca HF
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum

Reduced fecundity of vitamin D deficient rats.
Hickie JP, Lavigne DM, Woodward WD.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum

Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat.
Halloran BP, DeLuca HF.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum

Last edited by Zuleikaa : Thu, Feb-09-06 at 11:02.
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  #2   ^
Old Sat, Sep-23-06, 09:24
Zuleikaa Zuleikaa is offline
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Posts: 17,049
 
Plan: Mishmash
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I thought it would be good to bring this to the top again and add new information.

Vitamin D and PCOS

PCOS Symptoms
http://www.ovarian-cysts-pcos.com/pcos.html#sec4
Polycystic ovarian syndrome presents a complex and baffling array of symptoms, consisting of some combination of the following symptoms that vary with each individual:
• Multiple ovarian cysts
• Irregular or absent menses
• Infertility
• Acne
• Obesity or inability to lose weight (there’s a lot of evidence on vitamin D’s link to this)
• Excessive body or facial hair (hirsutism)
• Insulin resistance and possibly diabetes (there’s a lot of evidence on vitamin D’s link to this)
• Thinning of scalp hair
• Velvety, hyperpigmented skin folds (acanthosis nigricans)
• High blood pressure (there’s a lot of evidence on vitamin D’s link to this)
• Polycystic ovaries that are 2-5 times larger than healthy ovaries.
• Multiple hormone imbalances, commonly including:
o Androgens (testosterone)
o Cortisol
o Estrogens
o FSH (follicle stimulating hormone)
o Insulin.
o LH (luteinizing hormone)
o progesterone
o Prolactin.
o Thyroid hormones.
Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads.
Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Androgen receptor and vitamin D receptor in human ovarian cancer: growth stimulation and inhibition by ligands.
Ahonen MH, Zhuang YH, Aine R, Ylikomi T, Tuohimaa P.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

The relationship between endogenous oestradiol and vitamin D3 metabolites in serum and follicular fluid during ovarian stimulation for in-vitro fertilization and embryo transfer.
Potashnik G, Lunenfeld E, Levitas E, Itskovitz J, Albutiano S, Yankowitz N, Sonin Y, Levy J, Glezerman M, Shany S.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women.
Liu S, Song Y, Ford ES, Manson JE, Buring JE, Ridker PM.
http://www.ncbi.nlm.nih.gov/entrez/...earch&DB=pubmed

Evidence for alteration of the vitamin D-endocrine system in obese subjects.
Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum

Intakes of calcium and vitamin d predict body mass index in the population of Northern Norway.
Kamycheva E, Joakimsen RM, Jorde R.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum

The effects of light on the human body.
Wurtman RJ.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Skin diseases in consequence of endocrine alterations.
Krause W.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Acanthosis nigricans associated with insulin resistance : pathophysiology and management.
Hermanns-Le T, Scheen A, Pierard GE.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Retinoids and vitamin D analogues: action on nuclear transcription.
Griffiths CE.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
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  #3   ^
Old Wed, May-19-10, 10:21
LCCanadian's Avatar
LCCanadian LCCanadian is offline
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I found this helpful so I am bumping it up.
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  #4   ^
Old Wed, May-26-10, 21:58
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Shobha Shobha is offline
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Yes.

I supposedly had PCOS 6-7 years back, but now with (relatively) low carb, Vitamin D, K2, magnesium and omega-3 for the past 1.5 years or so .... periods are like clockwork.

I also delivered my son about 3 years ago, not sure if that helped too. I've read that 1-2 pregnancies are needed for women to be healthy.
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  #5   ^
Old Thu, May-27-10, 04:29
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Hutchinson Hutchinson is offline
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Plan: Dr Dahlqvist's
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The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. In conclusion, women with PCOS have mostly insufficient vitamin D levels, and vitamin D replacement therapy may have a beneficial effect on IR in obese women with PCOS.
remember such is the prevalence of Vitamin D deficiency that one does not have to wait for a 25(OH)D test before supplementing with 1000iu/daily for each 25lbs you weigh.
Supplementing with up to 10,000iu/daily is safe even in places where regular sun exposure is a practical possibility.
It takes roughly 3 months using an effective amount daily to achieve a stable level around 60ng/ml and a 25(OH)D test at that point will indicate if more is required or not. Remember human breast only produce vitamin D 3 milk when 25(OH)D levels are around 60ng/ml and at latitude 32n it takes around 6400iu/daily to ensure this happens. Further north will require more particularly in winter.

Don't forget that increasing Vitamin D allows your body to absorb more calcium from diet so supplementing with calcium should NOT be necessary but more magnesium and Vitamin K may be useful to transport and fix that extra calcium in bones as required.
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  #6   ^
Old Thu, May-27-10, 04:46
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Hutchinson Hutchinson is offline
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Plan: Dr Dahlqvist's
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Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome
Quote:
OBJECTIVES: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance.

Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS).

Hence, the aim of our study was to investigate the association of 25(OH)D levels and the components of the MS in PCOS women.

METHODS:
25(OH)D levels were measured by means of ELISA in 206 women affected by PCOS. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed.
RESULTS:
The prevalence of insufficient 25(OH)D levels (<30 ng/ml) was 72.8% in women with PCOS.

PCOS women with the MS had lower 25(OH)D levels than PCOS women without these features (17.3 vs 25.8 ng/ml respectively; P<0.05).

In multivariate regression analysis including 25(OH)D, season, body mass index (BMI), and age, 25(OH)D and BMI were independent predictors of homeostatic model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI; P<0.05 for all).

In binary logistic regression analyses, 25(OH)D (OR 0.86, P=0.019) and BMI (OR 1.28, P<0.001) were independent predictors of the MS in PCOS women.

We found significantly negative correlations of 25(OH)D levels with BMI, waist circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting and stimulated glucose, area under the glucose response curve, fasting insulin, HOMA-IR, HOMA-beta, triglycerides, and quotient total cholesterol/high-density lipoprotein (HDL) and positive correlations of 25(OH)D levels with QUICKI and HDL (P<0.05 for all).

CONCLUSION:
We demonstrate that low 25(OH)D levels are associated with features of the MS in PCOS women.

Large intervention trials are warranted to evaluate the effect of vitamin D supplementation on metabolic disturbances in PCOS women.


Bear in mind that the post that has been bumped is dated Thu, Feb-09-06 and Zuleikaa was detailing the evidence available then.

5 yrs later and the researchers are still pointing out that PCOS women are vitamin D deficient but nothing is generally done about it. It's a disgrace.
Also remember the level they are considering sufficient <30 ng/ml is HALF that required to enable breasts to produce the complete food for babies.
Who believes Vitamin D drops were available while humans were evolving?
When humans live near naked outdoor lives the 25(OH)D our bodies naturally attain and maintain is 60~80ng/ml So why don't we regard that as the starting point not the 30ng/ml that only prevents rickets. Many Caucasians only develop optimum BMD when 25(OH)D is well above 40ng/ml and we only begin to have reasonable Vitamin D reserves stored in muscle fat cells above 50ng/ml.
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  #7   ^
Old Tue, Jun-28-11, 20:29
kaylakala kaylakala is offline
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Is this why my children were jaundice when born? Lack of vitamin D?
I'm currently trying to conceive and if I can prevent that from happening again I'd be really happy.
I've been doing 5,000 IU daily for several months now.
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  #8   ^
Old Mon, Jul-18-11, 08:36
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madpiano madpiano is offline
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But doesn't just lying in the sun increase VitaminD?

So taking up jogging or any other outdoor sport without smothering oneself with sun block should do the trick?
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  #9   ^
Old Mon, Jul-18-11, 09:03
Zuleikaa Zuleikaa is offline
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Plan: Mishmash
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Quote:
Originally Posted by kaylakala
Is this why my children were jaundice when born? Lack of vitamin D?
I'm currently trying to conceive and if I can prevent that from happening again I'd be really happy.
I've been doing 5,000 IU daily for several months now.

Since the body requires 5,000-7,000 IU vitamin D per day, 5,000 IU per day won't help someone who already has a vitamin D deficiency, it requires more at the state to deal with the deficiency.
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  #10   ^
Old Mon, Jul-18-11, 09:09
Zuleikaa Zuleikaa is offline
Finding the Pieces
Posts: 17,049
 
Plan: Mishmash
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Location: Maryland, US
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Quote:
Originally Posted by madpiano
But doesn't just lying in the sun increase VitaminD?

So taking up jogging or any other outdoor sport without smothering oneself with sun block should do the trick?

Since vitamin D production can only be produced between 11-3 when the sun is at its highest and only during 7-9 months of the year most places, just being in the sun while clothed, while jogging is not sufficient.

For the body to generate sufficient vitamin D from the sun it requires that 80% of the body's skin be exposed to sun that enables vitamin D production for 20+ minutes. This is a short window in both time of day and season. Ability to produce vitamin D from the sun also depends on the person's age and skin color.
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  #11   ^
Old Sat, Aug-04-12, 13:33
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madpiano madpiano is offline
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Quote:
Originally Posted by Zuleikaa
Since vitamin D production can only be produced between 11-3 when the sun is at its highest and only during 7-9 months of the year most places, just being in the sun while clothed, while jogging is not sufficient.

For the body to generate sufficient vitamin D from the sun it requires that 80% of the body's skin be exposed to sun that enables vitamin D production for 20+ minutes. This is a short window in both time of day and season. Ability to produce vitamin D from the sun also depends on the person's age and skin color.


Have you got a reference for that? This is news to me
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  #12   ^
Old Sat, Aug-04-12, 17:05
Zuleikaa Zuleikaa is offline
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Posts: 17,049
 
Plan: Mishmash
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Obviously you haven't been reading the vitamin D thread, lol.

http://www.ajcn.org/content/67/6/1108.full.pdf

Yo can also read the papers by Dr. Holick and Dr. Vieth.
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