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  #1   ^
Old Thu, Jan-14-10, 15:42
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Default No relationship between saturated fat and heart disease [meta analysis of 21 studies]

No relationship between Saturated fat and heart disease! (Remember Dr. Krauss from GCBC?)

http://wholehealthsource.blogspot.c...icle-by-dr.html

Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease1,2,3,4,5
Quote:
Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.
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  #2   ^
Old Thu, Jan-14-10, 15:50
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Ok, here's a longer write up on the meta-study: http://high-fat-nutrition.blogspot....sis-krauss.html

A comment about something we can't see from the abstract is intriguing:
Quote:
Lot's of hand wringing in the conclusion inside the article.

"Our results suggested publication bias, such that studies with significant associations tended to be received more favorably for publication. If unpublished studies with null associations were included in the current analysis, the pooled RR estimate for CVD could be even closer to null."
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  #3   ^
Old Fri, Jan-15-10, 06:19
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Demi Demi is offline
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Default Two major studies conclude that saturated fat does NOT cause heart disease

from Dr Briffa's blog:

Quote:
Two major studies conclude that saturated fat does NOT cause heart disease

Posted By Dr John Briffa
On January 15, 2010

One of things I try and do on this blog is right what I see as nutritional wrongs. So, if there’s a common perception that artificial sweeteners are better than sugar for weight loss, but there’s really no evidence for that, then I’m inclined to write about it. If the evidence suggests that margarine is likely to be unhealthier than butter, I’ll write about that too. Similarly, I’ve been keen to point out that it appears that saturated fat, widely taken as to be artery-clogging and heart disease-provoking, is nothing of the sort.

I have written more than once about this, most recently here. This review of the literature found no evidence that saturated fat causes heart disease. And it’s a shame (in my opinion, anyway), that this study got no mainstream publicity.

The same, appears to be true, of a recent report published in the Annals of Nutrition and Metabolism [1]. You can read a complete version of this report here. The whole edition of this journal was dedicated to reporting an ‘Expert Consultation’ held jointly by the World Health Organization (WHO) and Food and Agriculture Organization (FAO) of the US. The consultation took a wide, sweeping look at the relationship between fats, physiology and health, and took place in late 2008. One of the things that was inevitably a focus of the consultation was the link between saturated fat and heart disease.

The ‘experts’ responsible for assessing this relationship looked at two lines of evidence: epidemiological studies and intervention studies. Let’s look at both in turn.

Epidemiological studies look at the relationship between factors (such as smoking and lung cancer, exercise and dementia, saturated fat and heart disease) in populations. These studies can only really tell us about associations between things, but can’t generally be used to inform us if one thing is causing another. Nevertheless, if saturated fat does truly cause heart disease (like we’ve been told for the last few decades), then the epidemiological evidence should show that higher levels of saturated fat are associated with a higher risk of heart disease (also known as ‘coronary heart disease’ or ‘CHD’ for short).

Well, according to the WHO/FAO report, there is no association. Here’s what the report states:

“Intake of SFA [saturated fatty acids] was not significantly associated with CHD mortality…”

and also

“SFA intake was not significantly associated CHD events [e.g. heart attacks]…”

And now on to intervention studies…

In such studies, individuals a subjected to some sort of intervention (such as a medication, increased exercise or dietary change). The relevant intervention in this area is to put people on a low saturated fat diet diet, and see how they fare compared to individuals who are not subjected to this change. Unlike epidemiological studies, intervention studies can prove ‘causal’ links between things. For example, if eating less saturated fat leads to a reduced risk of heart disease, then it’s a pretty good bet that saturated fat causes heart disease (all other things being equal).

So, what did the WHO/FAO report find with regard to relevant intervention studies? Here’s what:

“…fatal CHD was not reduced by…the low-fat diets…”

Just this week saw the publication of another huge study which assessed the relationship between saturated fat and heart disease [2]. This study was actually an amalgamation (meta-analysis) of 21 epidemiological studies. Taken all together, this review monitored almost 350,000 people over between 5 and 23 years. And here’s what it found:

1. No association between saturated fat and risk of heart disease

2. No association between saturated fat and risk of stroke


You know what this all means, don’t you? That there really is no evidence that saturated fat causes heart disease or cardiovascular disease generally.

Despite all this evidence to the contrary, I suspect the idea that saturated fat causes heart disease will perpetuate for some time. One reason for this has to do with cholesterol. There is some evidence that saturated fat puts cholesterol levels up, and we all know that cholesterol causes heart disease, right? So, if saturated fat puts cholesterol up, it must increased the risk of heart disease too. Well, this line of argument assumes that cholesterol causes heart disease, and actually the evidence shows this is far from assured. But even if it did, the logic is still faulty. We could use the same logic to claim that if something causes cholesterol to fall it must be good for heart health. So, if arsenic and cyanide reduce cholesterol, should we all be swigging these poisons down every day?

Anyway, while the ‘cholesterol causes heart disease’ paradigm is prevalent, I think saturated fat is going to be in the firing line. Shame, because at worst it appears an innocent bystander.

Another reason that saturated fat is likely to get a hard time for some time yet has to do with the fact that paradigms do tend to change very slowly. And at least some of this has to do with a reluctance some of us have to changing our minds about things we ‘know’. Some of us feel we ‘know’ saturated fat causes heart disease, because we’ve been told it so often and consistently we’re not even inclined to challenge this notion. And if we happen to be health professionals or academics who, at least in part, define ourselves by our ‘knowledge’ and ‘intelligence’, it can be mightily difficult to admit that we were wrong.

Not being a literary type, I’m not really a quote person either. But I do know at least one. It is British economist’s John Maynard Keynes’ assertion that “When the facts change, I change my mind. What do you do, sir?” How I would like to see health professionals and Government departments take a leaf out of Keynes’ book, and make pronouncements regarding saturated fat and other dietary factors based on science fact (not fiction).

References:

1. Fats and Fatty Acids in Human Nutrition. Annals of Nutrition and Metabolism, 2009; 55 (1-3).

2. Siri-Tarino PW, et al. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease Am J Clin Nutr 13 January 2010 [epub ahead of print].
http://www.drbriffa.com/blog/2010/0...-heart-disease/
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  #4   ^
Old Fri, Jan-15-10, 11:23
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Nancy LC Nancy LC is offline
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I think the post I did yesterday covered one of these studies: http://forum.lowcarber.org/showthread.php?t=406268
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  #5   ^
Old Sun, Jan-17-10, 07:56
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KMD KMD is offline
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The publication of the recent meta-analysis in American Journal of Clinical Nutrition is noteworthy because of the prestige of that journal. I don't recall them publishing similar articles in the past.

Now, maybe they'll finally review Gary Taubes' 2007 magnum opus, Good Calories, Bad Calories.

-Steve
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  #6   ^
Old Mon, Jan-18-10, 14:44
dmkorn dmkorn is offline
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The fact that saturated fat does not cause heart disease does not mean that carbohydrates cause it.
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  #7   ^
Old Mon, Jan-18-10, 14:48
kilton kilton is offline
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LOL -- thanks Dr. Science. Got any other words of wisdom for us?
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  #8   ^
Old Mon, Jan-18-10, 14:57
dmkorn dmkorn is offline
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Only because you asked so nicely, he you go. Don't be so quick to not challenge you preconceived notions.

"I am the wisest man alive, for I know one thing, and that is that I know nothing."
-Socrates

Socrates was of course being sarcastic, he was one of the wisest men in history. However, he was wise because he was always challenging his conclusions and searching for better explanations.


Quote:
Originally Posted by kilton
LOL -- thanks Dr. Science. Got any other words of wisdom for us?
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  #9   ^
Old Wed, Jan-20-10, 15:11
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Hutchinson Hutchinson is offline
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Krauss's New Article on Saturated Fat Intervention Trials
Quote:
Dr. Ronald Krauss's group just published another article in the American Journal of Clinical Nutrition, this time on the intervention trials examining the effectiveness of reducing saturated fat and/or replacing it with other nutrients, particularly carbohydrate or polyunsaturated seed oils. I don't agree with everything in this article. For example, they cite the Finnish Mental Hospital trial. They openly acknowledge some contradictory data, although they left out the Sydney diet-heart study and the Rose et al. corn oil study, both of which showed greatly increased mortality from replacing animal fats with polyunsaturated seed oils. Nevertheless, they get it right in the end:

Particularly given the differential effects of dietary saturated fats and carbohydrates on concentrations of larger and smaller LDL particles, respectively, dietary efforts to improve the increasing burden of CVD risk associated with atherogenic dyslipidemia should primarily emphasize the limitation of refined carbohydrate intakes and a reduction in excess adiposity.

This is really cool. Krauss is channeling Weston Price. If this keeps up, I may have no reason to blog anymore!

It's worth following the link and reading the comments as well.
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  #10   ^
Old Thu, Jan-21-10, 21:36
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cnmLisa cnmLisa is offline
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Default Evaluating the Association of Saturated Fat wiht Cardiovascular Disease

Quote:
<H2>Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease1,2,3,4,5

Patty W Siri-Tarino, Qi Sun, Frank B Hu and Ronald M Krauss







ABSTRACT

Background: A reduction in dietary saturated fat has generally been thought to improve cardiovascular health.

Objective: The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies.

Design: Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD.

Results: During 5–23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD. Consideration of age, sex, and study quality did not change the results.

Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat. Received for publication March 6, 2009. Accepted for publication November 25, 2009.
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  #11   ^
Old Thu, Jan-21-10, 22:40
howlovely howlovely is offline
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I really hope that more and more studies like this are brought to the forefront. It saddens me so much that so many people still buy in to the saturated fat myth. What ticks me off the most though, is that red meat-eaters have been SO vilified. They're portrayed as being stupid and gluttonous.
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  #12   ^
Old Thu, Jan-21-10, 22:43
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cnmLisa cnmLisa is offline
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Quote:
Originally Posted by howlovely
I really hope that more and more studies like this are brought to the forefront. It saddens me so much that so many people still buy in to the saturated fat myth. What ticks me off the most though, is that red meat-eaters have been SO vilified. They're portrayed as being stupid and gluttonous.


and don't forget...killing the environment
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  #13   ^
Old Thu, Jan-21-10, 22:51
howlovely howlovely is offline
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Oh right, I forgot about that one too. I am single-handedly messing up the environment because I like steak.

I wonder why people are so stubborn to give up this myth despite all evidence showing how wrong it is. Why is it so hard for us to change our beliefs when correct knowledge comes out? I mean, I know people will eventually (we no longer are "bled" when ill, for example). But in an age when the average person thinks themselves capable of rational, "scientific" thought, it would seem that a blunder as big as the sat fat myth would have been universally resolved by now.
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  #14   ^
Old Thu, Jan-21-10, 22:59
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cnmLisa cnmLisa is offline
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Quote:
Originally Posted by howlovely
Oh right, I forgot about that one too. I am single-handedly messing up the environment because I like steak.

I wonder why people are so stubborn to give up this myth despite all evidence showing how wrong it is. Why is it so hard for us to change our beliefs when correct knowledge comes out? I mean, I know people will eventually (we no longer are "bled" when ill, for example). But in an age when the average person thinks themselves capable of rational, "scientific" thought, it would seem that a blunder as big as the sat fat myth would have been universally resolved by now.


Next they're going to want to burn us at the steak
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  #15   ^
Old Sun, Jan-24-10, 09:02
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Hutchinson Hutchinson is offline
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