Thu, Apr-23-09, 16:59
|
 |
Senior Member
Posts: 2,036
|
|
Plan: VLC 4 days a week
Stats: 337/258/200
BF:
Progress: 58%
Location: Québec, Canada
|
|
The Adiponectin thread...
I Wish I could rename the title of this thread to The Adiponectin thread.
Quote:
|
Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. Adiponectin is exclusively secreted from adipose tissue into the bloodstream and is very abundant in plasma relative to many hormones. Levels of the hormone are inversely correlated with body fat percentage in adults, while the association in infants and young children is more unclear. The hormone plays a role in the suppression of the metabolic derangements that may result in type 2 diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and an independent risk factor for metabolic syndrome.
|
Quote:
|
Supplementation by differing forms of adiponectin were able to improve insulin control, blood glucose and triglyceride levels in mouse models.
|
Code:
Adiponectin affects:
* glucose flux
o gluconeogenesis
o glucose uptake
* lipid catabolism
o β-oxidation
o triglyceride clearance
* protection from endothelial dysfunction (important facet of atherosclerotic formation)
* insulin sensitivity
* weight loss
* control of energy metabolism.
Quote:
|
Because adiponectin is a novel hormone, no therapy has yet been developed with adiponectin and it may be some years before clinical trials commence. One obvious pharmaceutical treatment would be the administration of adiponectin; in mouse models such administration has shown positive effects.
|
http://en.wikipedia.org/wiki/Adiponectin
Quote:
|
Adiponectin can cause weight loss by raising metabolic rate while not affecting appetite
|
Quote:
|
When adiponectin, which is involved in glucose and lipid metabolism, was introduced into the cerebrospinal fluid of normal mice, they showed no changes in food intake, but their metabolism rose. "The animal burns off more calories, so over time loses weight, which was very fascinating because we knew that leptin caused weight loss by suppressing appetite and increasing metabolic rate," explains [lead author Rexford] Ahima. "Here we have another fat hormone that can cause weight loss but without affecting intake."
|
http://scienceandreason.blogspot.co...diponectin.html
Quote:
|
However, this new study shows that there is something else involved — exercise helps us shed belly fat because it increases the production of adiponectin.
|
Quote:
|
Adiponectin is a hormone produced in fat cells that increases the effectiveness of insulin. Studies show when we have plenty of adiponectin, not only is our insulin production lower, our blood sugar is better controlled, and that decreases our risk of diabetes and heart disease.
|
Quote:
|
However, when we gain weight, adiponectin production goes down. Weight that is gained in the belly, as opposed to weight gained more in the hips and thighs, is the weight that dramatically reduces adiponectin production. So, as you gain weight and adiponectin production drops, your weight just gets worse.
|
Quote:
|
But now we know that a way to get that adiponectin back up is through exercise! In the study, brisk walking mixed with light jogging 4-5 days per week for 40 minutes per session increased adiponectin in adult overweight males. Adiponectin levels rose 260% after two to three bouts of exercise despite unchanged body weight, and even remained elevated after 10 weeks.
|
http://www.totalhealthbreakthroughs...onectin-rising/
Quote:
|
The circadian clock controls energy homeostasis by regulating circadian expression and/or activity of enzymes involved in metabolism. Disruption of circadian rhythms may lead to obesity and metabolic disorders. We tested whether the biological clock controls adiponectin signaling pathway in the liver and whether fasting and/or high-fat (HF) diet affects this control. Mice were fed low-fat or HF diet and fasted on the last day. The circadian expression of clock genes and components of adiponectin metabolic pathway in the liver was tested at the RNA, protein, or enzyme activity level. In addition, serum levels of glucose, adiponectin, and insulin were measured. Under low-fat diet, adiponectin signaling pathway components exhibited circadian rhythmicity. However, fasting and HF diet altered this circadian expression; fasting resulted in a phase advance, and HF diet caused a phase delay. In addition, adenosine monophosphate-activated protein kinase levels were high during fasting and low during HF diet. Changes in the phase and daily rhythm of clock genes and components of adiponectin signaling pathway as a result of HF diet may lead to obesity and may explain the disruption of other clock-controlled output systems, such as blood pressure and sleep/wake cycle, usually associated with metabolic disorders.
|
High-Fat Diet Delays and Fasting Advances the Circadian Expression of Adiponectin Signaling Components in Mouse Liver
This would all fit with Pennington's hypothesis: http://forum.lowcarber.org/showthread.php?t=394699
I'm currently testing this. I made a mix of dried potato powder and whey & egg protein powder (vanilla flavor and stevia sweetened). I make it so there is 70g carbs and 90g proteins, which are my Dr K. ratios. Then I add boiling water to it until it reaches the texture of mashed potatoes. That's my food for an entire day.
Plus I continue taking my supplements.
- Vitamin D3 5000iu/d
- Magnesium 300mg/d
- Omega (swiss labs) 2400mg/d
- B 100 complex/d
- The Right C 1000mg/d
- Norwegian Kelp 1500mg/d (1.5 mg iodine)
- Maca pills (don't remember amount)
- Glucosamine Sulfate 3000mg/d
Patrick
Last edited by Valtor : Thu, Apr-23-09 at 20:41.
|
Linear Mode
