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  #1   ^
Old Fri, Aug-17-18, 02:37
Demi's Avatar
Demi Demi is offline
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Default A Rare Genetic Aversion to Sweets Could Be Key to Fighting Obesity

From Bloomberg.com

A Rare Genetic Aversion to Sweets Could Be Key to Fighting Obesity

An anomaly in the way some people process fructose could help find new drugs for diseases linked to weight.


https://www.bloomberg.com/news/feat...ighting-obesity
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  #2   ^
Old Fri, Aug-17-18, 06:52
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teaser teaser is offline
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Plan: mostly milkfat
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The aversion to sweets in interesting, I wonder if this is general, or specific to fructose? Would these people like a little splenda (they might never find out, if they don't like sweet foods in the first place, they're unlikely to be looking for replacements.

The idea of fructose in the blood and urine being harmless--yes, but this is in people who've had the condition since birth. And this aversion to candy--so presumably this is the fructosuria and fructosemia that results from fairly low intake of fructose from not so sweet veggies, and small bits in processed foods etc. We don't know that blocking the enzyme will result in aversion to sugar in somebody who didn't lack the enzyme throughout development, or that the higher levels of sugar intake that might result if they lack this aversion and the resulting higher fructosuria and fructosemia would be harmless. I wouldn't want to be the first human guinea pig eating 100 plus pounds of sugar a year that's common these days and peeing out the fructose.

Quote:
Since Pfizer believes the drug is likely to work best in people who consume high amounts of fructose, but also be effective in most people with fatty liver and NASH, knowing how much unnatural fructose is consumed is crucial.


Well, no. There's nothing here that justifies concentrating on "natural" sugars.
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  #3   ^
Old Fri, Aug-17-18, 06:56
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teaser teaser is offline
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Plan: mostly milkfat
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Richard Johnson's name doesn't pop up as much as it should. Anybody hoping to develop an aversion to fructose without taking drugs could do worse than reading his books or listening to interviews of him.

https://www.youtube.com/watch?v=3W2zSN0JOa8

Here he's interviewed by Krusty the Clown, but it's still worth a listen.
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  #4   ^
Old Fri, Aug-17-18, 07:38
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Ms Arielle Ms Arielle is offline
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I often hear my 2 teens say " that's too sweet" --just by changing to mostly LC and dropping the baked goods their preferences changed.
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  #5   ^
Old Fri, Aug-17-18, 07:38
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BillyHW BillyHW is offline
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It's a good thing these people didn't count calories to match intake with energy expenditure, otherwise they would have starved to death.

Maybe they weighed themselves and looked at themselves in the mirror each weak, saw that they were getting underweight and made sure to eat a little bit more the following week, in order to maintain a normal body weight.

I wonder what they thought of their fat friends who just couldn't push themselves away from the table a bit sooner.
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  #6   ^
Old Fri, Aug-17-18, 07:54
Zei Zei is offline
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They have to throw in that "unnatural" fructose word so as not to provoke all those people out there who think fructose-laden fruits are so good for you. Smart business strategy to not rock the boat with people's strongly held beliefs about foods. The obvious non-pharmaceutical solution is to just not eat the fructose, but realistically a lot of people probably won't do that. I wouldn't take (or need) such a drug and would be leery of side effects like whether all that fructose would promote bladder infections, etc. but who knows? Maybe it'll succeed and help some people who'd otherwise be a lot sicker. A big thing I see coming from this is the recognition and focus including a major pharmaceutical company on fructose/sugar not fat as causative in obesity and fatty liver disease. Should Pfizer succeed in producing such a drug they'll of course want to put a lot into marketing it to doctors and potential patients. And considering much of doctors' continuing education is provided by big pharma, that could go a long way toward educating both doctors and the public that fructose not fat is the problem. That'd be great having the corrective information being pushed by a major company respected by many conventional doctors and then the information spread by all those conventional doctors to patients unlikely to accept it from other sources than hearing it from their own conventional doctor.
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