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  #136   ^
Old Wed, May-09-18, 03:32
JEY100's Avatar
JEY100 JEY100 is offline
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Hi Walnut, hope you are feeling well.

You likely found this interview with Jason Fung on 7 days. As he states, there are more studies on the 3-5 day fasts. https://www.rsng.com/categories/mov...-against-cancer

The most coverage in the media was following Dr Valter Longo's study on 3 day fasts.
https://www.cell.com/cell-stem-cell...5909(14)00151-9. One example
https://www.forbes.com/sites/steven...m/#2c02e0933c93

8 excellent fasting references following this short article by Dr Champ. https://www.myhealthwire.com/news/breakthroughs/924

EDIT: later found this longer article with more references, this would be a good start to reduce the search results from below only to those most relevant. https://www.canceractive.com/cancer...ink.aspx?n=3408


I have other fasting/ cancer articles if you PM an email. One link was to this interview with Dr Seyfried, you can read the transcript (thankfully) I remember this interview as detailed, but no time to reread it right now.

Searching PubMed there were over 6000 results for cancer and fasting, add 7 day there were still over 250, so depends how sciencey you want to be and how much time to dig through them Maybe add Valter Longo to the search terms cancer and fasting to get a more manageable result? https://www.ncbi.nlm.nih.gov/pubmed...d+fasting+7+day. See EDIT above.

To quote teaser today over in the Dr Fung thread, "Fasting is sexy right now, so we see these studies" Longevity studies for 3,5, and 7 day fasts, will often mention cancer too, leading to these search results. And of course, the IDM website has numerous posts related to autophagy, Cancer and fasting, e.g. https://idmprogram.com/fasting-and-...agy-fasting-25/ The new Obesity Code Network FB Page may be helpful for you.

Last edited by JEY100 : Wed, May-09-18 at 05:34.
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  #137   ^
Old Wed, May-09-18, 15:21
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walnut walnut is offline
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Wow! Thank you so much Janet!
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  #138   ^
Old Thu, May-10-18, 04:13
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JEY100 JEY100 is offline
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You're welcome. Somehow lost the Seyfried interview link in my edit.
Adding it here (from 3 years ago, it was a controversial interview to say the least)

"Water Fasts" as a Potential Tactic to Beat Cancer
https://thequantifiedbody.net/water...to-beat-cancer/

Although added CancerActive for information and research supporting a specific topic, it includes most complementary and integrative alternate cancer treatments known worldwide, and am concerned it could steer patients away from standard of care with good success rates. Along with info on fasting and Keto there are some pretty flakey treatments, use caution

If I were recently diagnosed, would now consider buying the Ralph Moss Reports to evaluate both conventional and alternative treatments. Heard of this resource from Derek Green, I did not know about him 11 years ago. http://cancerdecisions.com

Last edited by JEY100 : Thu, May-10-18 at 05:27.
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  #139   ^
Old Thu, Jun-07-18, 05:39
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teaser teaser is offline
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https://www.sciencedaily.com/releas...80606132706.htm

Sticking this here because it deals with another aspect of cancer as a metabolic disease.

Quote:
Excess zinc in muscles contributes to wasting syndrome in cancer
Discovery could lead to the development of treatments for a debilitating condition implicated in 30 percent of all cancer deaths

It's estimated that nearly one-third of all cancer deaths are caused not by the cancer itself but by cachexia -- a debilitating muscle-wasting syndrome that affects an estimated 80 percent of advanced cancer patients. Cachexia is linked to reduced tolerance for cancer therapy, poor quality of life, and accelerated death, but there are no effective treatments and its cause is still largely unknown.

A new study from Columbia University Irving Medical Center suggests that an overload of zinc in patients' muscles may be the culprit. The findings, published online today in Nature Medicine, could pave the way for the development of drugs to treat or prevent muscle wasting in advanced cancer patients.

Cachexia occurs in many types of cancers, including pancreatic, gastrointestinal, lung, and head and neck cancers. Yet the condition remains poorly understood, due in part to limited research funding in this area, difficulty developing animal models that accurately replicate the condition in human cancer, and a lack of reliable biomarkers to help diagnose cachexia early and monitor its progression during cancer treatment.

"There's a common misconception that cachexia is just a nutritional problem caused by a loss of appetite stemming from the cancer or its treatments," says study leader Swarnali Acharyya, PhD, assistant professor of pathology & cell biology in the Institute of Cancer Genetics at Columbia University Vagelos College of Physicians and Surgeons. "Cachectic patients are typically given appetite stimulants, but these remedies only help temporarily and cannot reverse cachexia. As cachexia continues to break down muscle, patients often become too weak to tolerate standard doses of anti-cancer therapies, and their doctors have to scale back treatment. Cachexia can also weaken the muscles of the diaphragm and the heart, causing many cancer patients to die from respiratory or heart failure. To find better ways of treating this condition, we need to learn more about its underlying cause and the molecular mechanisms associated with this syndrome."

In the study, Acharyya's team looked in the muscles of mice with cachexia to see if they could find differences compared with normal muscles. The analysis revealed greater activity of a protein called ZIP14, which is typically expressed in liver cells to facilitate metal transport but was found to be abnormally expressed in muscles of the cancer models. They also found high levels of ZIP14 in samples of muscle tissue from cancer patients with cachexia, suggesting a link between ZIP14 and cachexia in people.

Excess zinc uptake in muscle leads to muscle wasting in cancer, the researchers found, by breaking down mature muscle cells and preventing stem cells from making new muscle fibers.

The reason why ZIP14 pumps more zinc into muscles in cachexia was traced back to the systemic effects of cancer. The researchers found that two factors -- TNF-alpha and TGF-beta, which are associated with advanced cancer -- increase ZIP14 expression in muscle.

"We often think cancer injures the body by spreading and invading vital organs," Acharyya says. "But cancer can also injure in another way, by releasing substances that affect other areas of the body that are cancer-free. This is an area that is often overlooked in cancer biology research, but addressing it during cancer treatment could have an important impact on patient survival and quality of life."

The discovery of zinc and ZIP14's connection with cachexia may lead to ways to reduce cachexia's impact on patients. In the study, reducing ZIP14 in muscle cells markedly reduced cachexia, suggesting that drugs that inhibit ZIP14 could improve cancer survival and quality of life.

"Zinc is essential for maintaining many functions in our body, and is often taken as a supplement," says Acharyya. "But excess zinc supplementation may not always be a good thing, because we saw that giving excess zinc supplements to mice with tumors accelerated their muscle wasting and weight loss. With more translational studies, clinicians and patients may need to reconsider the practice of using zinc supplements, especially if they have tumors commonly associated with cachexia."

Dr. Acharyya is currently designing strategies to inactivate ZIP14 with Anup Biswas, PhD, one of the lead authors of this study. These efforts could lead to the development of therapies to combat cancer cachexia in the future.


Besides wasting muscle, cachexia can provide fuel for cancer, keeping cancer from feeding/getting material for growth from muscle sounds like a good target. I guess there's also the issue of fuel partitioning, if muscle protein synthesis and energy use goes down.
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  #140   ^
Old Fri, Jun-08-18, 02:45
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JEY100 JEY100 is offline
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There were many media articles during the ASCO conference this weekend, of the thousands of papers and Press releases, it is always interesting which ones get press and which ones never see the light of day. Unless I missed it, the case studies involving the Ketogenic Diet are the later...so adding them here. http://forum.lowcarber.org/showthread.php?t=480470 To be fair a case study is weak and donít often get press.
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