I'm extremely sensitive to carbohydrates too, but I doubt I have that gene.
Quote:
The faulty genes, the scientists think, may be interfering with the sensation of satiety so that even though the body is full, the mind wants more.
Drugs which are known to help weight loss, such as Ozempic and Wegovy, work by interfering with the brain’s processing of satiety and therefore stop the sensation of needing to eat.
However, this category of drugs, known as GLP-1s, work by interfering with a different pathway in the brain, and will likely have no impact on the hunger caused by the flawed Bassoon gene.
Prof Yeo added: “Bassoon probably does slow down the effectiveness of how these drugs will work, I think. We don’t know yet, just to be clear, but the drugs will probably still work and you’ll still lose weight on them. I predict that weight-loss drugs will work in people with this gene, but not as well.”
The true mystery the scientists are now trying to crack is why this gene, which is present from birth, only takes effect in adulthood.
Future studies on animals will induce the genetic condition as it is too uncommon to easily study in people and see what, and when, the gene becomes active.
It is possible, the scientists say, that it is linked to increased autonomy in adulthood or is a hormone-induced phenomenon brought on by puberty.
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From the way it was described, it sounds like the gene is so rare that it doesn't have anything at all to do with sensitivity to any particular type of food or macronutrient, just a tendency to not feel satiated after eating so that you're always hungry - which in a way does sound a LOT like the way I feel on carbs, but I reach satiety much more easily and don't get the feeling of hunger for several hours on LC. Eating a lot of carbs though, I might feel excessively full, but still ravenously hungry.
One would think that these people have tried going LC to see if it affects their weight and hunger. I mean surely they asked them if they've been on diets, what kind, and if they were successful in losing weight, or still hungry all the time. Because here's a hint - if there's a diet where you're not hungry all the time, it's going to be lower in carbs.
Surely they they asked such questions, right? (Yeah, I know... probably not, at least not in a way that clearly showed LC made any difference at all)
Then again... the ones who conducted this study probably started with the hypothesis that maybe it's a gene that causes obesity, let's see if there is one.
Still, the link to a specific gene causing obesity seems extremely low, since it's so rare compared to obesity itself - and that should be a very big clue that it's not the cause of obesity in general. And the people who have that gene are experiencing the exact same insatiable appetite as many without the gene.
And yet most people studied (obese or not) will eat similar macro-nutrient proportions because that's the proportions of macro-nutrients available in the stores and at restaurants. The naturally thin people we all know have never had to white knuckle it through a diet (but instead as Oprah put it "you aren't even thinking about food"). They're eating similar macro proportions, but they stop eating when satiated and are satiated for hours on end. So the reasoning would be that it can't be the macro-nutrient balance of the diet that's the problem, because we have lots of people who are eating a similar macro-nutrient balance but are not obese, even if they're becoming more rare. Ergo, the obese are just eating too much altogether.
So it goes back to WHY are they eating too much? It's been determined that obesity is not simply a moral failing, and has been declared to be a disease treatable with appetite controlling drugs (apparently the obese don't have enough GLP-1 in their systems, just like T2 diabetics don't have enough insulin, even though they're pumping out tons of it). So the hunt is on to figure out why they don't have enough GLP-1 to control their appetites... hence the reasoning that perhaps it's a gene that causes the problem.
Only problem with the results of this study is that only accounts for a very tiny percentage of those who are obese.
[Sarcasm]Maybe it's the macro-nutrient proportions? Nah, that's crazy talk! Everyone knows that we've determined the proper macro-nutrient proportions for an ideal diet! And you NEED at least 60% carbs! Keep those fats down below 25%! Protein? Well, if you really must... but make sure most (if not all) of them are plant based! [ /sarcasm]