Yes. I'm not sure if it was in the original article that started this thread, or another one, but somewhere there was mention of "restrained calories" or some such. A few years ago there was a rhesus monkey calorie restriction study, and it worked--calorie restricted monkeys had a lower rate of death from "age-related disease," like cancer, heart disease etc. But they only lived longer once you weeded out those that died from infection--more calorie restricted monkeys died, at a young age, due to infection. That raises a few questions--did the calorie restriction make the monkeys more susceptible to infection? It certainly seems plausible. Does it work the same way in humans? Lots of studies with names like



are to be found in PubMed. And it makes sense for younger people to be more susceptible to nutritional stress. I've seen the suggestion in various places that there's sort of a trade-off--better-fed populations having stronger immune systems, but increase susceptibility to auto-immunity issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475230/