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Old Fri, Mar-18-16, 15:20
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amergin amergin is offline
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Posts: 277
 
Plan: Low carb, suff. protein
Stats: 115/103/95 Male 191cm
BF:
Progress: 60%
Location: dublin
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Quote:
Originally Posted by teaser

One thing I think could be a factor--that glucagon that didn't decrease, it's possible that the effect of glucagon on the liver's blood glucose production is partly driven by the liver's capacity to produce glucose. In a prolonged fast, the rate of gluconeogenesis is substrate-driven, as protein and carbohydrate metabolism decrease through the fast in favour of fat, availability of amino acids for glucose production decreases.

None of this says that glucagon isn't a good target for intervention, if you could find a way to do it, it would bring down glucose, that would bring down insulin.

Also, none of my babbling really detracts from Dr. Fung's statement that it's the insulin, stupid--because failure of glucagon to decrease with the carbohydrate feeding is likely due to insulin resistance by some cell or other--either the cells that themselves produce glucagon, or the cells that produce other hormones etc. that drive glucagon release.


Teaser are you familiar with this bit of info from Prof Roger Unger.

http://diabeticmediterraneandiet.co...diabetes-model/
also
https://www.youtube.com/watch?v=VjQkqFSdDOc

He proposes a mechanism for the failure to lower glucagon appropriately and suggests it's a bigger issue than heretofore acknowledged.
Doesn't give a definite solution but may identify a mechanism, which is a first step.
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