Thu, Jan-04-18, 10:15
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Senior Member
Posts: 15,075
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Plan: mostly milkfat
Stats: 190/152.4/154
BF:
Progress: 104%
Location: Ontario
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There's a study, "Functional hypoglycemia in early latent diabetes," it used to be free, now it's not. Seems to be happening a lot lately, maybe that's actually a good sign, there's renewed interest in this sort of thing.
Anyways, a couple of hundred obese subjects, given a five hour glucose tolerance test. A fair number showed normal glucose tolerance at the second hour, but most of these showed "early latent diabetes," which is what the researchers chose to call a delayed reactive hypoglycemia, the lowest numbers, below basal, showed up around the four hour mark. Evidence of excessive insulin, a different sort of glucose intolerance than the extended elevation in blood glucose used to diagnose diabetes or prediabetes.
One of the more common undesired side effects of gastric bypass is hypoglycemia, which fits well with the desired side effect of diabetes reversal. Maybe that could be seen as latent hypoglycemia, just as further weight gain might bring somebody from latent diabetes to frank type II diabetes, weight loss could uncover a propensity for hypoglycemia that type II/insulin resistance would actually protect from.
https://www.ncbi.nlm.nih.gov/pubmed/23169787
Quote:
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Long-term, intermittent, insulin-induced hypoglycemia produces marked obesity without hyperphagia or insulin resistance: a model for weight gain with intensive insulin therapy.
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Quote:
Abstract
A major side effect of insulin treatment of diabetes is weight gain, which limits patient compliance and may pose additional health risks. Although the mechanisms responsible for this weight gain are poorly understood, it has been suggested that there may be a link to the incidence of recurrent episodes of hypoglycemia. Here we present a rodent model of marked weight gain associated with weekly insulin-induced hypoglycemic episodes in the absence of diabetes. Insulin treatment caused a significant increase in both body weight and fat mass, accompanied by reduced motor activity, lowered thermogenesis in response to a cold challenge, and reduced brown fat uncoupling protein mRNA. However, there was no effect of insulin treatment on total food intake nor on hypothalamic neuropeptide Y or proopiomelanocortin mRNA expression, and insulin-treated animals did not become insulin-resistant. Our results suggest that repeated iatrogenic hypoglycemia leads to weight gain, and that such weight gain is associated with a multifaceted deficit in metabolic regulation rather than to a chronic increase in caloric intake.
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Fun mouse study. You can't throw a rock without hitting a mouse study where increased food intake isn't necessary for them to get fatter. |