I recently finished listening to the 3-part podcast interview of Chris Masterjohn, PhD by Chris Kresser, LAc. (I think I now have an honorary masters in cholesterol studies.) Anyway, Masterjohn thinks that LDL particle size is not a causal factor for cardiovascular disease (CVD). Rather, he thinks that particle size is a marker for time the particle has spend in the bloodstream. In turn, that's a marker for LDL receptor health, the only real causal link to CVD. There's no lab test for LDL receptor number or receptivity, which would be preferable.

But Masterjohn pointed out a number of limitations to the particle size testing. The biggest one is that different companies' test, purporting to measure particle size, give significantly different results for blood samples taken from the same person at the same time. The second is that there's no accepted standard for what the VAP test calls pattern A and B; they are standards made up by the lab itself.