Sat, Sep-16-17, 07:38
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Senior Member
Posts: 4,041
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Plan: Very LC, Higher Protein
Stats: 227/186/185
BF:
Progress: 98%
Location: Herndon, VA
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Interesting contrasting articles. I'm encouraged by the findings of the dynamics between acetoacetate and methylglyoxal. That we know and acknowledge that the metabolism is incredibly complex is another important observation that is necessary context in all this.
Dr. Mike's article dovetails nicely with the Science Daily article. As we peel back the layers of the process, Dr. Mike's conclusion is one encouraging takeaway:
Quote:
The only thing that reliably does increase lifespan is caloric restriction (CR) in lab animals, at least. CR is thought to work in great measure by decreasing the number of free radicals fired off in the mitochondria as a consequence of the mitochondria having less food that they have to process. The mitochondria make their own antioxidants – one of which is glutathione – to help protect themselves from the free radicals they generate. Anything that increases the glutathione within the mitochondria is going to help increase longevity and decrease many of the ravages of disease, many of which stem from excess mitochondrial free radical production. This study indicates that a ketogenic diet significantly increases the production of glutathione within the mitochondria, which is right where you want it, especially to protect the mitochondrial DNA.
Granted, this study was a rat study, and I’m not a big fan of extrapolating rat studies to human studies. But, rat mitochondria aren’t that different from ours so it’s a little easier to make the leap of faith. So, I would recommend for a long and healthy life that you ketonate as much as possible. Let those ketones do the job of blood sugar, keeping your blood sugar low. Lower sugar, lower AGEs, Lower AGEs, longer life.
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The Hyperlipid observations? Well, we've got a lot to learn yet.
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