Metformin gave my mother horrible gastric issues for years. At some point she was taking Invokana. She died of kidney and liver failure on May 28 of this year. She was 70 and recovery would have required transplants, so they sent her home on hospice. However, I cannot say that having poorly managed diabetes for 20 years wasn't what caused her organs to fail instead of the med. She wasn't in good health for years as a result of complications caused by diabetes. That and she refused to eat healthy and would only drink diet soda (no water)...I love that woman, but she was such a stubborn mule sometimes.