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  #37   ^
Old Sun, Jun-18-17, 16:16
M Levac M Levac is offline
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Posts: 6,498
 
Plan: VLC, mostly meat
Stats: 202/200/165 Male 5' 7"
BF:
Progress: 5%
Location: Montreal, Quebec, Canada
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This is a tangent to the main topic so I'll end with this. Insulin-induced lipohypertrophy is well documented in diabetics type 1. Do a simple search and find literally tons of info on that. Second, there's a drug called Adipotide or prohibitin-targeting peptide 1 (PTP-1), currently in experimental trial (interestingly for cancer rather than for obesity, probably because of its effect on insulin sensitivity and blood glucose), that can shrink fat tissue permanently, just like liposuction but it's a drug not surgery. This drug works only on the obese, there's no effect on the lean. The implication here is that the obese grow fat tissue (by increasing the number of fat cells, and by increasing the number of blood vessels needed to supply blood to those new fat cells), and this new fat tissue is fundamentally different from the fat tissue we're born with, different from the fat tissue we have before we grow fatter through insulin and hyperinsulinemia.

Insulin-induced lipohypertrophy is the name of the phenomenon. The mechanism is preadipocyte (a sort of stem cell, specifically for adipocytes) proliferation and differentiation, a quick search will give ample info on that too.

It's likely that those docs who still believe fat cells don't grow in number, also believe we grow fatter because of excess calories, and thus they have no clue about the actual mechanisms involved in growing fat tissue either way.
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