The most obvious is deficiency.

No amount of jumping can create vitamin B12 (or the essential of your choice). Conversely, we need B12 to jump for any significant amount of time, or at all if deficiency is severe.

With hormones, it's a similar principle. A testosterone deficiency for example, cannot be overcome by any amount of weight lifting, in spite of the stimulus this creates. Lifting weights stimulates testosterone production, so it rises, but only as high as the regulatory systems allow. If these systems are disrupted to a point where testosterone production is lower, that will be the maximum level achievable by lifting weights alone. Conversely, testosterone alone can cause muscle growth (among other things, like more hair and more manly features, etc) independently of the amount of weights we lift, this is even more true as a child grows because that's when hormones have the greatest effects. Growth hormone is the most potent hormone (opposite insulin), same principle.