I agree that with our current knowledge, all signs point to sugar, particularly the fructose component in sucrose and HFCS, as the primary culprit. Fatty Liver Disease and Insulin resistance develop from consumption of these sugars, and they've become ever-present in our processed foods and soda. The issue is that many people don't know what sugar is and where it's found. As sugar ingredients have been added to foods throughout the world (starting to be the equivalent of a western diet), the diabetes and obesity rates have spiked, and the metabolic syndrome symptoms of CVD, CHD, HBP, GERD, Alzheimer's, are on the rise in these countries and regions. Comparing this to those cultures that previously consumed a diet high in starches (glucose primary), the difference today is staggering.