Kyle Mamounis's talk vs. sugar causing insulin resistance is interesting. I think it's wrong-headed, but interesting.

He starts with the debate resolution, "Sugar causes insulin resistance," which to me is a non-starter. If I say, "Sugar is the cause of insulin resistance," you only have to show conditions under which sugar doesn't cause insulin resistance, to show that sugar isn't the cause.

Not that I know much about philosophy or engineering, but a useful bit of philosophy here might be to not use philosophy to solve an engineering problem. I don't care whether sugar is the "ultimate" cause, I care about whether I'll benefit by avoiding it.