Are you just interested in losing weight or are you starting a fitness program you want to follow for the rest of your life?

Forget what is "best" and do what you enjoy. If you are a bodybuilder at heart, lift. If you are a distance runner at heart, run. If you want to beat the crap out of people, take up MMA.

If you don't love what you do, you'll never be consistent enough at your workouts for them to give you much benefit anyway.

The bottom line is that fat is lost in the kitchen. Fitness is built in the gym. Don't confuse the two goals. They are compatible, but different.