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Old Mon, Jun-18-18, 17:49
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s93uv3h s93uv3h is offline
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Recent instagram post by Dr. Rhonda Patrick:

A new study found sulforaphane (found in broccoli sprouts) improved behavior and social responsiveness in children with autism spectrum disorder. It also found that clinical improvements were correlated with two urinary metabolites known to be involved in redox metabolism, which sulforaphane is known to affect.

This study builds upon findings from a prior randomized, placebo-controlled trial which showed sulforaphane improved symptoms of autism in young adults.

This study did NOT use sprouts. Instead, they used a supplement called Avmacol that has the precursor to sulforaphane (called glucoraphanin) along with the active enzyme (called myrosinase) that converts glucoraphanin into sulforaphane.
This particular supplement has been validated by researchers at The Cullman Chemoprotection Center at Johns Hopkins University. See my interview with Johns Hopkins scientist Dr. Jed Fahey for more info on some of the supplements out there and also the early work on autism and the brain.

The net dose of sulforaphane for the pills involved in this trial is around 40 μmol per two tablets of the supplement. All enrolled children were provided weight-based dosing of sulforaphane (~ 2.5 μmol glucoraphanin per lb of body weight). You can find the episode on sulforaphane with Dr. Fahey along with show notes and a transcript on the foundmyfitness episodes page:
https://www.foundmyfitness.com/episodes/jed-w-fahey

Link to the new trial:
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. 5-30-2018

Link to the previous RCT:
Sulforaphane treatment of autism spectrum disorder (ASD) 10-28-2014
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