Active Low-Carber Forums - View Single Post - A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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Highlights

•A low-carbohydrate, ketogenic diet extends longevity in adult male mice
•Motor function, memory, and muscle mass are preserved in aged ketogenic mice
•Protein acetylation is increased in the liver and skeletal muscle of ketogenic mice

Summary

Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.

Full text: http://www.cell.com/cell-metabolism...4131(17)30490-4