Active Low-Carber Forums - View Single Post - Brain 'switch' tells body to burn fat after a meal

Quote:

Originally Posted by M Levac

No.

No.

If eating (therefore insulin) causes browning (therefore greater Eout) then how is obesity created in the first place, when obesity is said to be created by more eating (therefore more insulin, therefore more browing, therefore more greater Eout)? See what I mean by "No."?

I'd like to cite diabetes type 1, where there's no insulin, there's hyperphagia, and there's emaciation. Hyperphagia therefore expected insulin, but no insulin because diabetes type 1 therefore no browing, yet no fat accumulation. Pfft, go to hospital, diagnose, treat, inject insulin, voila - fat accumulation. Be not-smart, inject insulin in same spot for years, voila - localized excess fat accumulation in a process called insulin-induced lipohypertrophy. Eat more carbs, inject more insulin (because eat more carbs - insulin dose depends on carbs, you see), voila - more fat accumulation all over the place. Incidentally, when that happens, the insulin-induced lipohypertrophy becomes invisible due to the amount of fat everywhere. This suggests that insulin-induced lipohypertrophy is also a system-wide phenomenon rather than just localized to the injection site(s). Anyways, the whole thing contradicts the idea that insulin somehow causes adipocytes to go brown after a meal.

Finally, biology doesn't waste for no reason. If there's excess energy, it will be used, not merely disposed.

What they're describing here is a sort of feedback mechanism, which they posit ought to keep humans from becoming overweight. That doesn't rule out insulin being obesogenic--it just says that there are things to counter this.

Also--who says it's wasted? That sort of depends on your perspective. GCBC had a section on adolescent pigs--fed a very low protein diet the pigs just ate more. Energy was "wasted"--but maybe in the service of providing sufficient
protein and other nutrients to allow normal growth. So it would be disposed of, and the useful work that's produced might be its own disposal.

Excessive amounts of insulin in the periphery hijacking the system doesn't rule out there being other roles played by insulin when things are working right.