Reading the full text of the research on which these press releases and reviews are based does give a much better idea of what the researchers did and enables you to understand a little better the significance of their findings.

They were investigating how IKKb/NF-kB causes hypothalamic insulin and leptin resistance. I found their conclusion that "Overnutrition Subverts the Innate Immune Response of Hypothalamic IKKb/NF-kB" and their explanation of how persistent signals to the CNS under conditions of overnutrition can sometimes cause an innate immune like response directed by IKKb/NF-kB in the hypothalamic neurons and how this process affects the neuronal regulation of energy balance was quite interesting.

As we know calorie restriction leads to longer life this helps explain why. I think it supports low carbohydrate dieting as these diets seem to naturally lead to lower calorie intake. I think it also implies we should take Intermittent Fasting more seriously.