The aversion to sweets in interesting, I wonder if this is general, or specific to fructose? Would these people like a little splenda (they might never find out, if they don't like sweet foods in the first place, they're unlikely to be looking for replacements.

The idea of fructose in the blood and urine being harmless--yes, but this is in people who've had the condition since birth. And this aversion to candy--so presumably this is the fructosuria and fructosemia that results from fairly low intake of fructose from not so sweet veggies, and small bits in processed foods etc. We don't know that blocking the enzyme will result in aversion to sugar in somebody who didn't lack the enzyme throughout development, or that the higher levels of sugar intake that might result if they lack this aversion and the resulting higher fructosuria and fructosemia would be harmless. I wouldn't want to be the first human guinea pig eating 100 plus pounds of sugar a year that's common these days and peeing out the fructose.



Well, no. There's nothing here that justifies concentrating on "natural" sugars.