I agree mice are different, but I don't think studies really capture the difference. Wild mice not being subject to at least periods of high fat diet doesn't seem that likely to me. Give a mouse a high fat diet, and give it an enriched environment, which can mean as little as a running wheel, which the animals use voluntarily, can do a lot to reverse their supposed inability to tolerate a high fat diet. I think you have to assume that their natural environment is probably a bit more stimulating than just adding a running wheel to a cage. Throw in environment-induced meal-timing, natural light cycles, etc.

A drug that targets fat cell uptake of glucose would probably work, but also be diabetogenic unless combined with a safe diet.