My husband suffered from clinical depression. He tried the meds and that made things much worse. I got him on a good supplemental program of D3, B-Complex, Magnesium, etc.... and that has done wonders! Way more than the meds ever did for him. He is not a low carber, but he did find out that he was D deficient, years after I had started him on supplements...and he was taking 1,000 mg a day then, now he has to take about 3,000 mg a day of the D3.