I don't mean to sound flippant but the only response I can come up with is 'so?'.

You can spend your life chasing a number or you can choose to live happy and healthy the best way you know how.

There could be six-thousand reasons why we in developed nations have higher cholesterol, environmental toxins, the stress of a modern life, even the genetic component of a few hundred generations eating a sub-optimal diet (side-note: was watching a documentary on the BBC about food science, the stuff they used to add to food back in the 1800's included lead and well-known poisons, we really have it much better in some respects nowadays).

High cholesterol could be a protective mechanism for any one of the million differences between us and primitive society (in women higher cholesterol is associated with less risk of disease and longer life). We probably aren't the same average height as various hunter-gatherer societies either, I ain't gonna sweat it.