I definitely think so! I had a hysterectomy in 1991 and was immediately put on hormones. I was already chubby at that point (about 30 lbs overweight), so I didn't notice much of a gain at that time. But over the next few years, along with some MAJOR stress in my life (my dh's illness and death included in that time frame), I put on about 15 more pounds. Then after I remarried in '97 my doctor took me off the hormone pellets and put me on oral tablets. I have ballooned up 50 pounds since then. Granted, I wasn't eating like I should have, but I still blame a great deal of it on that. Along with the fact HRT causes acne!! arrrggghhh I'm like a fat 12 year old now!