| doreen T |
Thu, Jul-13-17 07:12 |
So it's not dust itself causing problems, but rather the modern-day chemicals found in it ... flame-retardants, fungicides, pesticides, phthalates .. the list goes on and on.
Quote:
Seven of the samples triggered the pre-adipocytes to develop into mature fat cells, the researchers found.
But once this process happens, it can never be reversed, even if someone loses vast amounts of weight.
And once they reach a certain size, new fat cells are created.
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Here's the study abstract:
Quote:
Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells
Obesity and metabolic disorders are of great societal concern and generate significant human health care costs. Recently, attention has focused on the potential for environmental contaminants to act as metabolic disruptors. This study sought to evaluate the adipogenic activity of indoor house dust extracts and a suite of semivolatile organic chemicals (SVOCs) that are often ubiquitously detected in indoor environments. 3T3-L1 cells were exposed to extracts of indoor dust or individual SVOCs and assessed for triglyceride accumulation and preadipocyte proliferation. Ten of 11 house dust extracts exhibited significant triglyceride accumulation and/or proliferation at environmentally relevant levels (<20 μg of dust/well), and significant adipogenic activity was also exhibited by 28 of the SVOCs. Notably, pyraclostrobin, dibutyl phthalate, tert-butyl-phenyl diphenyl phosphate, and the isopropylated triaryl phosphates (ITPs) exhibited near maximal or supra-maximal triglyceride accumulation relative to the rosiglitazone-induced maximum. The adipogenic activity in house dust occurred at concentrations below EPA estimated child exposure levels, and raises concerns for human health impacts, particularly in children. Our results delineate a novel potential health threat and identify putative causative SVOCs that are likely contributing to this activity.
http://pubs.acs.org/doi/abs/10.1021/acs.est.7b01788
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